Aging and obesity are closely related. A key change in the adipose tissue during the aging process is the decline of lipolysis. The excitation of the sympathetic nerve system is a key pathway to promote lipolysis, but the underlying mechanism remains unclear. In this work, and aging models with and without tyrosine hydroxylase (TH) knockdown were treated with total saponins from (TSPJs), and the expression of lipolysis-related proteins was examined. It was found that TSPJs could promote the expression of lipolysis-related genes and TH in adipocytes both and , and the expression of lipolysis-related genes was downregulated after TH knockdown. It was inferred that TSPJs could promote the excitation of sympathetic nerves by increasing the expression of TH in adipose tissue, which positively regulated the expression of lipases to revitalize lipolysis. The results suggested that TSPJs resisted aging-induced obesity and could be a potential medication for weight management.

中文翻译：

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参参总皂苷通过酪氨酸羟化酶信号通路促进衰老脂肪的脂肪分解


衰老与肥胖密切相关。衰老过程中脂肪组织的一个关键变化是脂肪分解能力的下降。交感神经系统的兴奋是促进脂肪分解的关键途径，但其潜在机制仍不清楚。在这项工作中，用来自（TSPJ）的总皂苷处理有或没有酪氨酸羟化酶（TH）敲低的衰老模型，并检查了脂解相关蛋白的表达。结果发现，TSPJs能够促进脂肪细胞中脂解相关基因和TH的表达，并且TH敲低后脂解相关基因的表达下调。推测TSPJs可以通过增加脂肪组织中TH的表达来促进交感神经兴奋，从而正向调节脂肪酶的表达，从而重振脂肪分解。结果表明，TSPJ 可以抵抗衰老引起的肥胖，并可能成为体重管理的潜在药物。