The crucial roles of innate and acquired immunity in the pathogenesis of allergic diseases have been well highlighted based on molecular mechanisms. Thus, the modulation of unregulated and unabated inflammatory responses is a therapeutic strategy in allergic diseases. One of the most important natural compounds with a high immune modulation and anti-inflammation potency is quercetin, found in various fruits and vegetables, namely onions, shallots, apples, and berry crops. Therefore, in this study, we reviewed the influences of quercetin against allergic conditions, including asthma, allergic rhinitis, atopic dermatitis, conjunctivitis, and anaphylaxis. Scientific databases, including PubMed, Scopus, the Web of Sciences, and EMBASE, were searched in English until March 2024. Quercetin’s beneficial effects have been attributed to its anti-cancer, anti-viral, anti-oxidant, and anti-inflammatory activities, and also a decrease in pro-inflammatory cytokines, leukotrienes production, inhibition of histamine release, and suppression of interleukin IL-4 production. It can reduce the production of antigen-specific IgE antibodies and improve the Th1/Th2 balance. These qualities of quercetin can be used as a strategy to treat asthma, allergic rhinitis, atopic dermatitis, conjunctivitis, and anaphylaxis. According to the findings of these investigations, quercetin may have a beneficial influence on allergy illnesses.

中文翻译：

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槲皮素是一种有前景的抗过敏性疾病功能性食品添加剂：全面、机制的综述

基于分子机制，先天性和获得性免疫在过敏性疾病发病机制中的关键作用已得到充分强调。因此，调节不受调节和未减弱的炎症反应是过敏性疾病的一种治疗策略。槲皮素是具有高度免疫调节和抗炎功效的最重要的天然化合物之一，存在于各种水果和蔬菜中，即洋葱、青葱、苹果和浆果作物中。因此，在本研究中，我们回顾了槲皮素对过敏性疾病的影响，包括哮喘、过敏性鼻炎、特应性皮炎、结膜炎和过敏反应。截至 2024 年 3 月，科学数据库（包括 PubMed、Scopus、Web of Sciences 和 EMBASE）均以英文进行检索。槲皮素的有益作用归因于其抗癌、抗病毒、抗氧化和抗炎活性。以及促炎细胞因子、白三烯产生的减少、组胺释放的抑制以及白细胞介素 IL-4 产生的抑制。它可以减少抗原特异性IgE抗体的产生，改善Th1/Th2平衡。槲皮素的这些特性可用作治疗哮喘、过敏性鼻炎、特应性皮炎、结膜炎和过敏反应的策略。根据这些调查的结果，槲皮素可能对过敏性疾病有有益的影响。