The development of new functional foods that can potentially reduce the risk of diseases, such as osteoporosis, has received increasing attention in recent years. Here we demonstrated that silk sericin-based functional food (SSBF) exerted preventive and therapeutic effects against bone loss. Sericin isolated at 70 °C for 60 min from the cocoon of Bombyx mori stimulated osteoblast differentiation by increasing osteoblastic gene expression while inhibiting receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation . Micro-computed tomography analysis revealed that pre- and post-oral administration of SSBF increased bone mass in ovariectomized mouse model . Furthermore, dynamic bone histomorphometry analysis revealed that SSBF enhanced osteoblast activity and suppressed bone resorption by reducing the number of osteoclasts. These findings indicated the potential role of SSBF in preventing and being a therapeutic candidate for osteoporosis.

中文翻译：

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丝胶类骨质疏松症防治功能食品


近年来，能够降低骨质疏松症等疾病风险的新型功能性食品的开发受到越来越多的关注。在这里，我们证明了基于丝胶的功能食品（SSBF）对骨质流失具有预防和治疗作用。在 70°C 下从家蚕茧中分离丝胶 60 分钟，通过增加成骨细胞基因表达刺激成骨细胞分化，同时抑制核因子 κB 配体受体激活剂 (RANKL) 诱导的破骨细胞分化。显微计算机断层扫描分析显示，口服 SSBF 前后给药可增加卵巢切除小鼠模型的骨量。此外，动态骨组织形态计量学分析表明，SSBF 通过减少破骨细胞数量来增强成骨细胞活性并抑制骨吸收。这些发现表明 SSBF 在预防骨质疏松症和治疗骨质疏松症方面具有潜在作用。