The toxicological effect between co-existed antibiotics and metal ions was dangerous to the ecological environment and public health. However, the rapid quantification tools with convenience, accuracy and low cost for the detection of multiple targets were still challenging. Herein, a portable tri-color ratiometric fluorescence paper sensor was constructed by coupling of blue carbon dots and fluorescence imprinted polymer for down/up conversion simultaneous detection of tetracycline and sulfamethazine. Interestingly, the cascade detection of aluminum ion was also realized based on the individual detection system of tetracycline without the assistance of complex coupling reagents. The detection limits of smartphone method for the visual detection of tetracycline, sulfamethazine and aluminum ion were calculated as 0.014 μM, 0.004 μM and 0.019 μM, respectively. The portable fluorescence paper sensor was applied for the visual detection of tetracycline, sulfamethazine and aluminum ion in actual samples successfully with satisfactory recoveries. With the advantages of rapidness, low cost, and portability, the developed portable fluorescence paper sensor provided a new strategy for the visual real-time detection of multiple targets.

中文翻译：

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便携式三色比例荧光纸传感器，用于智能视觉检测双抗生素和铝离子

抗生素与金属离子共存的毒理学作用对生态环境和公众健康造成危害。然而，方便、准确、低成本的多目标检测快速定量工具仍然具有挑战性。本文通过蓝色碳点和荧光印迹聚合物的耦合构建了便携式三色比率荧光纸传感器，用于下/上转换同时检测四环素和磺胺二甲嘧啶。有趣的是，基于四环素个体检测系统，无需复杂偶联试剂的辅助，也实现了铝离子的级联检测。计算得出智能手机法目视检测四环素、磺胺二甲嗪和铝离子的检出限分别为0.014 μM、0.004 μM和0.019 μM。便携式荧光纸传感器成功应用于实际样品中四环素、磺胺二甲嘧啶和铝离子的目视检测，回收率满意。所开发的便携式荧光纸传感器具有快速、低成本、便携等优点，为多目标的视觉实时检测提供了新的策略。