Bromophenols (BPs) are a class of ubiquitous emerging halogenated pollutants. Their 19 congeners are problematically separated and detected. This work described the separation and detection of 19 BP congeners by gas chromatography-mass spectrometry (GC-MS). Investigations into the derivatization of bromophenols were carried out using two silylation reagents (N,O-bis(trimethylsilyl)trifluoroacetamide and N-methyl-N-(trimethylsily)trifluoroacetamide), two alkylation reagents (methyl iodide and trimethylsilyldiazomethane) and acetic anhydride prior to GC-MS analysis. Optimal chromatographic separation, sensitivity, and linearity were achieved after BP derivatization using acetic anhydride, featuring the equipment detection limits of 0.39–1.26 pg and correlation coefficients of 0.9948–0.9999 (linear range: 0.5–250 ng mL−1) for all 19 BP congeners. Furthermore, the simultaneous determination of 19 bromophenols and 19 bromoanisoles, common environmental transformation products of BPs, is also demonstrated. The improved analytical performance on GC-MS after derivatization would benefit investigations on the environmental origins, behaviors and fates of BPs and their environmental metabolites.

中文翻译：

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衍生化后气相色谱-质谱法 (GC-MS) 同时测定 19 种溴苯酚

溴酚 (BP) 是一类普遍存在的新兴卤化污染物。它们的 19 种同源物在分离和检测时存在问题。这项工作描述了通过气相色谱-质谱 (GC-MS) 分离和检测 19 种 BP 同系物。使用两种甲硅烷基化试剂（N,O-双（三甲基甲硅烷基）三氟乙酰胺和 N-甲基-N-（三甲基甲硅烷基）三氟乙酰胺）、两种烷基化试剂（碘甲烷和三甲基甲硅烷基重氮甲烷）和乙酸酐对溴苯酚的衍生化进行了研究。 GC-MS 分析。使用乙酸酐对 BP 进行衍生化后，获得了最佳的色谱分离、灵敏度和线性度，所有 19 个 BP 的设备检测限为 0.39–1.26 pg，相关系数为 0.9948–0.9999（线性范围：0.5–250 ng mL−1）同系物。此外，还演示了同时测定 19 种溴苯酚和 19 种溴茴香醚（BP 的常见环境转化产物）。衍生化后 GC-MS 分析性能的提高将有利于对 BP 及其环境代谢物的环境起源、行为和命运的研究。