Cyanidin-3--glucoside (C3G), a natural antioxidant, plays multiple physiological or pathological roles in maintaining human health; thereby, designing advanced sensors to achieve specific recognition and high-sensitivity detection of C3G is significant. Herein, an imprinted-type electrochemiluminescence (ECL) sensing platform was developed using core-shell Ru@SiO-CMIPs, which were prepared by covalent organic framework (COF)-based molecularly imprinted polymers (CMIPs) embedded in luminescent Ru@SiO cores. The C3G-imprinted COF shell not only helps generate a steady-enhanced ECL signal, but also enables specific recognition of C3G. When C3G is bound to Ru@SiO-CMIPs with abundant imprinted cavities, resonance energy transfer (RET) behavior is triggered, resulting in a quenched ECL response. The constructed Ru@SiO-CMIPs nanoprobes exhibit ultra-high sensitivity, absolute specificity, and an ultra-low detection limit (0.15 pg mL) for analyzing C3G in food matrices. This study provides a means to construct an efficient and reliable molecular imprinting-based ECL sensor for food analysis.

中文翻译：

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基于分子印迹的Ru@SiO2嵌入共价有机框架复合物用于电化学发光检测花青素-3-O-葡萄糖苷

Cyanidin-3-glucoside（C3G）是一种天然抗氧化剂，在维持人体健康中发挥多种生理或病理作用；因此，设计先进的传感器来实现C3G的特异性识别和高灵敏度检测具有重要意义。在此，使用核壳Ru@SiO-CMIPs开发了一种印迹型电化学发光（ECL）传感平台，该平台是通过嵌入发光Ru@SiO核中的基于共价有机框架（COF）的分子印迹聚合物（CMIPs）制备的。印有C3G的COF外壳不仅有助于产生稳定增强的ECL信号，而且还能够特异性识别C3G。当 C3G 与具有丰富印迹空腔的 Ru@SiO-CMIP 结合时，会触发共振能量转移 (RET) 行为，从而导致 ECL 响应猝灭。构建的 Ru@SiO-CMIPs 纳米探针在分析食品基质中的 C3G 时表现出超高灵敏度、绝对特异性和超低检测限 (0.15 pg mL)。这项研究为构建用于食品分析的高效可靠的基于分子印迹的 ECL 传感器提供了一种方法。