To further enhance the application of nobiletin (an important active ingredient in fruits), we used ultrasonic homogenization-assisted antisolvent precipitation to create ultrafine particles of nobiletin (UPN). DMSO was used as the solvent, and deionized water was used as the antisolvent. When ultrasonication (670 W) and homogenization (16000 r/min) were synergistic, the solution concentration was 57 mg/mL, and the minimum particle size of UPN was 521.02 nm. The UPN samples outperformed the RN samples in terms of the inhibition of porcine pancreatic lipase, which was inhibited (by 500 mg/mL) by 68.41 % in the raw sample, 90.34 % in the ultrafine sample, and 83.59 % in the positive control, according to the data. Fourier transform infrared spectroscopy analysis revealed no chemical changes in the samples before or after preparation. However, the crystallinity of the processed ultrafine nobiletin particles decreased. Thus, this work offers significant relevance for applications in the realm of food chemistry and indirectly illustrates the expanded application potential of nobiletin.

中文翻译：

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超声均质协同反溶剂沉淀制备川陈皮素超细颗粒及α-葡萄糖苷酶和猪胰脂肪酶体外抑制效果评价

为了进一步提高川陈皮素（水果中的重要活性成分）的应用，我们采用超声波均质辅助反溶剂沉淀法制备川陈皮素（UPN）超细颗粒。使用DMSO作为溶剂，并且使用去离子水作为反溶剂。当超声处理（670 W）和均质（16000 r/min）协同作用时，溶液浓度为57 mg/mL，UPN的最小粒径为521.02 nm。 UPN 样品在抑制猪胰脂肪酶方面优于 RN 样品，原始样品中猪胰脂肪酶的抑制率（500 mg/mL）为 68.41%，超细样品中为 90.34%，阳性对照中为 83.59%。根据数据。傅里叶变换红外光谱分析显示样品在制备前后没有化学变化。然而，加工后的超细川陈皮素颗粒的结晶度降低。因此，这项工作为食品化学领域的应用提供了重要的相关性，并间接说明了川陈皮素的扩展应用潜力。