Herein, we unveil the synthesis and characterization of a squaraine () and Pluronic F127 based nanoparticles. These nanoparticles exhibited fascinating photothermal and photodynamic properties. Experimental results showed that was efficient photosensitizers that could produce reactive oxygen species (ROS) with singlet oxygen quantum yield of 0.019. Furthermore, we found that nanoparticles could increase the local temperature gradually from 24.0 °C to 54.2 °C over the course of 10 min. nanoparticles had a photothermal efficiency of 52%. Finally, in vitro phototherapy efficiency of nanoparticles were elucidated using human melanoma cells (SK-MEL 30/An1). nanoparticles did not exhibit any discernible toxicity in the dark. For photodynamic therapy (PDT), SK-MEL 30 cells were illuminated with red light, which was followed by laser irradiation (808 nm, 1.0 W/cm) for photothermal therapy (PTT). It is noteworthy that up to 57% of melanoma cells could be killed by nanoparticles when dual therapy was carried out. Our data clearly showed that the treatment of nanoparticles with two different wavelengths produced a combined dual phototherapy effect on cancer cells. Overall, nanoparticles were truly efficient photosensitizers for PDT and PTT.

中文翻译：

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含有方酸菁的聚合物纳米粒子可实现癌细胞的光动力和光热治疗

在此，我们揭示了基于方酸菁 (squaraine) 和 Pluronic F127 的纳米颗粒的合成和表征。这些纳米粒子表现出令人着迷的光热和光动力特性。实验结果表明，该光敏剂可产生单线态氧量子产率为0.019的活性氧（ROS）。此外，我们发现纳米颗粒可以在 10 分钟内将局部温度从 24.0 °C 逐渐升高到 54.2 °C。纳米粒子的光热效率为52%。最后，利用人黑色素瘤细胞 (SK-MEL 30/An1) 阐明了纳米粒子的体外光疗效率。纳米粒子在黑暗中没有表现出任何明显的毒性。对于光动力疗法（PDT），用红光照射SK-MEL 30细胞，然后用激光照射（808 nm，1.0 W/cm）进行光热疗法（PTT）。值得注意的是，当进行双重治疗时，纳米颗粒可以杀死高达 57% 的黑色素瘤细胞。我们的数据清楚地表明，两种不同波长的纳米颗粒的治疗对癌细胞产生了联合的双重光疗效果。总体而言，纳米颗粒是真正有效的 PDT 和 PTT 光敏剂。