Herein, we report a copper(I)-free method for labeling the trifluoroacetyl group with positron-emitting carbon-11 (t_1/2 = 20.4 min) or fluorine-18 (t_1/2 = 109.8 min) as part of our exploration of radiolabeled fluoroforms to access new radiolabeled chemotypes of interest for tracer development. Treatment of alkyl esters and aryl esters, containing electron-donating or electron-withdrawing groups, with [¹¹C/¹⁸F]fluoroform in the presence of strong base, gave [¹¹C/¹⁸F]trifluoromethyl ketones as novel radiolabeling synthons in moderate to high yields within 15 minutes.

中文翻译：

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由烷基酯或芳基酯和[11C/18F]氟仿无铜(I)合成[11C/18F]三氟甲基酮

在此，我们报告了一种无铜（I ）的方法，用正电子发射碳 11（ t _1/2 = 20.4 分钟）或氟 18（t _1/2 = 109.8 分钟）标记三氟乙酰基，作为我们研究的一部分探索放射性标记氟仿，以获得用于示踪剂开发的新放射性标记化学型。在强碱存在下，用[ ¹¹ C/ ¹⁸ F]氟仿处理含有给电子或吸电子基团的烷基酯和芳基酯，得到[ ¹¹ C/ ¹⁸ F]三氟甲基酮，作为新型放射性标记合成子。 15分钟内达到高产量。