Despite years of research, malaria remains a significant global health burden, with poor diagnostic tests and increasing antimalarial drug resistance challenging diagnosis and treatment. While ‘single-omics’-based approaches have been instrumental in gaining insight into the biology and pathogenicity of the Plasmodium parasite and its interaction with the human host, a more comprehensive understanding of malaria pathogenesis can be achieved through 'multi-omics' approaches. Integrative methods, which combine metabolomics, lipidomics, transcriptomics, and genomics datasets, offer a holistic systems biology approach to studying malaria. This review highlights recent advances, future directions, and challenges involved in using integrative metabolomics approaches to interrogate the interactions between Plasmodium and the human host, paving the way towards targeted antimalaria therapeutics and control intervention methods.

尽管经过多年的研究，疟疾仍然是全球的一个重大健康负担，诊断测试不佳和抗疟药物耐药性不断增加，对诊断和治疗提出了挑战。虽然基于“单组学”的方法有助于深入了解疟原虫寄生虫的生物学和致病性及其与人类宿主的相互作用，但通过“多组学”方法可以更全面地了解疟疾发病机制。综合方法结合了代谢组学、脂质组学、转录组学和基因组学数据集，为研究疟疾提供了整体系统生物学方法。这篇综述重点介绍了使用综合代谢组学方法来探究疟原虫与人类宿主之间相互作用的最新进展、未来方向和挑战，为靶向抗疟疾治疗和控制干预方法铺平了道路。