The gene cell division cycle associated 5 (CDCA5), also called sororin, has oncogenic characteristics and is upregulated in various carcinomas. Nevertheless, the involvement of CDCA5 in ovarian cancer (OC), a highly aggressive form of cancer, and the underlying mechanism of metastasis remain inadequately investigated. The bioinformatics data revealed a negative correlation between the patient’s survival and CDCA5 expression, which was overexpressed in OC. Functional assays also confirmed high expression levels of CDCA5 in OC tissues and cells. This suggests that CDCA5 may potentially enhance the motility, migration, and proliferation of OC cells invitro. It impedes DNA damage and apoptosis in OC cells, inhibiting xenograft development in nude mice. The RNA sequencing results suggest CDCA5 is majorly associated with biological functions related to the extracellular matrix (ECM) and influences the transforming growth factor (TGF) signaling pathway. Moreover, subsequent functional investigations elucidated that CDCA5 facilitated the migration and invasion of OC cells viathe TGF-β1/Smad2/3 signaling pathway activation. CDCA5 may be a strong potential therapeutic target for the treatment and management of OC.

中文翻译：

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CDCA5通过激活TGF-β1通路促进人卵巢癌细胞的细胞侵袭和迁移

基因细胞分裂周期相关 5 (CDCA5)，也称为 sororin，具有致癌特征，并且在各种癌症中表达上调。然而，CDCA5 在卵巢癌（OC）（一种高度侵袭性的癌症）中的参与以及转移的潜在机制仍未得到充分研究。生物信息学数据显示，患者的生存率与CDCA5表达呈负相关，CDCA5在OC中过度表达。功能测定还证实了 OC 组织和细胞中 CDCA5 的高表达水平。这表明CDCA5可能潜在地增强体外OC细胞的运动、迁移和增殖。它能阻止 OC 细胞的 DNA 损伤和细胞凋亡，抑制裸鼠异种移植物的发育。 RNA测序结果表明CDCA5主要与细胞外基质（ECM）相关的生物学功能相关，并影响转化生长因子（TGF）信号通路。此外，随后的功能研究阐明CDCA5通过TGF-β1/Smad2/3信号通路激活促进OC细胞的迁移和侵袭。 CDCA5 可能是治疗和管理 OC 的一个强大的潜在治疗靶点。