PurposeNon‐invasive measurement of cerebral venous oxygenation (Yv) is of critical importance in brain diseases. The present work proposed a fast method to quantify regional Yv map for both large and small veins.MethodsA new sequence was developed, referred to as TRU‐VERA (T2 relaxation under velocity encoding and rapid acquisition, which isolates blood spins from static tissue with velocity‐encoding preparation, modulates the T2 weighting of venous signal with T2‐preparation and utilizes a bSSFP readout to achieve fast acquisition with high resolution. The sequence was first optimized to achieve best sensitivity for both large and small veins, and then validated with TRUST (T2 relaxation under spin tagging), TRUPC (T2 relaxation under phase contrast), and accelerated TRUPC MRI. Regional difference of Yv was evaluated, and test–retest reproducibility was examined.ResultsOptimal Venc was determined to be 3 cm/s, while recovery time and balanced SSFP flip angle within reasonable range had minimal effect on SNR efficiency. Venous T2 measured with TRU‐VERA was highly correlated with T2 from TRUST (R2 = 0.90), and a conversion equation was established for further calibration to Yv. TRU‐VERA sequences showed consistent Yv estimation with TRUPC (R2 = 0.64) and accelerated TRUPC (R2 = 0.79). Coefficient of variation was 0.84% for large veins and 2.49% for small veins, suggesting an excellent test–retest reproducibility.ConclusionThe proposed TRU‐VERA sequence is a promising method for vessel‐specific oxygenation assessment.

中文翻译：

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通过速度编码准备和快速采集对脑静脉氧合进行血管特异性定量

目的无创测量脑静脉氧合（Yv）对于脑部疾病至关重要。目前的工作提出了一种快速量化区域 Y 的方法v方法开发了一种新序列，称为 TRU‐VERA (T2速度编码和快速采集下的松弛，通过速度编码制剂将血液自旋与静态组织隔离，调节 T2用 T 对静脉信号进行加权2‐准备并利用 bSSFP 读数来实现高分辨率的快速采集。首先对序列进行优化，以实现大静脉和小静脉的最佳灵敏度，然后使用 TRUST (T2自旋标记下的弛豫），TRUPC（T2相衬下的松弛）和加速 TRUPC MRI。 Y的区域差异v结果最佳Venc确定为3 cm/s，而恢复时间和合理范围内的平衡SSFP翻转角对SNR效率的影响最小。静脉T2使用 TRU-VERA 测量的结果与 T 高度相关2来自信任（右2= 0.90），并建立了转换方程以进一步校准Yv。 TRU-VERA 序列显示一致的 Yv使用 TRUPC 进行估计（右2= 0.64) 和加速 TRUPC (右2= 0.79）。大静脉的变异系数为 0.84%，小静脉的变异系数为 2.49%，表明具有出色的重测重现性。结论所提出的 TRU-VERA 序列是一种有前途的血管特异性氧合评估方法。