Investigating the association between inflammation mediated by mushroom consumption and mild cognitive impairment in Chinese older adults,Food & Function

当前位置： X-MOL 学术 › Food Funct. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Investigating the association between inflammation mediated by mushroom consumption and mild cognitive impairment in Chinese older adults
Food & Function ( IF 6.1 ) Pub Date : 2024-03-25 , DOI: 10.1039/d3fo04263d
Lili Chen _{1,

2,

3} , Rongyan Qiu ₄ , Bixia Wang _{3,

5} , Jinxiu Liu ₃ , Xiuli Li ₃ , Zhaoyi Hou ₃ , Tingting Wu ₄ , Huizhen Cao ₃ , Xinli Ji ₃ , Ping Zhang ₃ , Yuping Zhang ₃ , Mianxiang Xue ₃ , Linlin Qiu ₃ , Linlin Wang ₃ , Yongbao Wei _{1,

6} , Mingfeng Chen _{1,

7}

Affiliation

Background: Chronic inflammatory stimulation is a major risk factor for mild cognitive impairment. Mushroom consumption and inflammatory factors may play an important role in the pathogenesis of mild cognitive impairment. Additionally, consuming mushrooms can reduce the levels of inflammatory cytokines and preserve cognitive function. Therefore, this study aimed to investigate the relationship between mushroom consumption and serum inflammatory cytokines and mild cognitive impairment (MCI). Methods: Binary logistic regression was used to determine the relationship between mushroom consumption and MCI in 550 participants. Subsequently, mediation analysis was used to analyze the relationship between mushroom consumption, inflammatory factors, and the Montreal Cognitive assessment (MoCA) score in 248 participants. Results: Mushroom consumption was associated with MCI (odds ratio = 0.623, 95% confidence interval = 0.542–0.715, P < 0.001). The association between mushroom intake and MCI was mediated by interleukin-6 (IL-6) and hypersensitive C-reactive protein (hs-CRP), and the MoCA score was 12.76% and 47.59%, respectively. Conclusion: A high intake of mushrooms was associated with a low risk of MCI. Serum inflammatory factors including IL-6 and hs-CRP play a partial mediating role between mushroom intake and the MoCA score, and the underlying mechanism needs to be further explored.

更新日期：2024-03-25

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>