Background: The role of serum urate (SU) levels in the development of chronic obstructive pulmonary disease (COPD) remains a topic of debate, and it is unclear whether a healthy diet can mitigate the impact of SU on COPD risk. The objective of this study is to examine whether and to what extent a healthy diet can reduce the risk of COPD in relation to SU levels. Methods: The cohort analysis included 155 403 participants from the UK Biobank. SU levels were measured at the time of recruitment. A healthy diet score was calculated based on the consumption of vegetables, fruits, fish, processed meats, unprocessed red meat, whole grains, and refined grains. The Cox proportional hazards model was used to analyze the associations between SU levels, a healthy diet score, and the risk of COPD. Results: During a follow-up period of 1 409 969 person-years, 2918 incident cases of COPD were identified. Compared with the lowest SU level group, the hazard ratio (HR) and 95% confidence interval (CI) for COPD were 1.17 (1.03, 1.34) for participants with the highest SU level (hyperuricemia), indicating a positive association. Additionally, a dose–response relationship was observed between SU levels and the incidence of COPD (P-value for overall <0.0001). In the combined effect analysis, compared to individuals with high SU (hyperuricemia) + a low diet score (diet score <4), those with normal SU + a high diet score (diet score ≥4) had a HR (95% CI) of 0.75 (0.65, 0.87) for COPD. Conclusions: In summary, there is a positive association between SU levels and the risk of COPD. Furthermore, a healthier diet can mitigate the risk of COPD associated with high SU levels.

中文翻译：

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血清尿酸和健康饮食与慢性阻塞性肺病发病率的联合关联：英国生物银行研究的结果

背景：血清尿酸盐（SU）水平在慢性阻塞性肺疾病（COPD）发展中的作用仍然是一个争论话题，目前尚不清楚健康饮食是否可以减轻SU对COPD风险的影响。本研究的目的是检验健康饮食是否以及在多大程度上可以降低与 SU 水平相关的慢性阻塞性肺病 (COPD) 风险。方法：队列分析包括来自英国生物银行的 155 403 名参与者。 SU 水平在招募时进行测量。健康饮食得分是根据蔬菜、水果、鱼类、加工肉类、未加工红肉、全谷物和精制谷物的消耗量计算的。 Cox 比例风险模型用于分析 SU 水平、健康饮食评分和 COPD 风险之间的关联。结果：在 1 409 969 人年的随访期间，发现了 2918 例 COPD 病例。与SU水平最低组相比，SU水平最高（高尿酸血症）的参与者的COPD风险比（HR）和95%置信区间（CI）为1.17（1.03，1.34），表明呈正相关。此外，还观察到 SU 水平与 COPD 发病率之间存在剂量反应关系（总体P值<0.0001）。在综合效应分析中，与高SU（高尿酸血症）+低饮食评分（饮食评分<4）的个体相比，正常SU+高饮食评分（饮食评分≥4）的个体的HR（95％CI）慢性阻塞性肺病 (COPD) 为 0.75 (0.65, 0.87)。结论：总而言之，SU 水平与 COPD 风险之间存在正相关关系。此外，更健康的饮食可以降低与高SU水平相关的慢性阻塞性肺病的风险。