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Dimethyl phthalate induced cardiovascular developmental toxicity in zebrafish embryos by regulating MAPK and calcium signaling pathways
Science of the Total Environment ( IF 8.2 ) Pub Date : 2024-03-21 , DOI: 10.1016/j.scitotenv.2024.171902 Bianneng Cao 1 , Haotian Kong 1 , Chuanlin Shen 1 , Gaimei She 2 , Shuimiao Tian 1 , Haojie Liu 1 , Lishuang Cui 1 , Yun Zhang 1 , Qiuxia He 1 , Qing Xia 1 , Kechun Liu 1
Science of the Total Environment ( IF 8.2 ) Pub Date : 2024-03-21 , DOI: 10.1016/j.scitotenv.2024.171902 Bianneng Cao 1 , Haotian Kong 1 , Chuanlin Shen 1 , Gaimei She 2 , Shuimiao Tian 1 , Haojie Liu 1 , Lishuang Cui 1 , Yun Zhang 1 , Qiuxia He 1 , Qing Xia 1 , Kechun Liu 1
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Dimethyl phthalate (DMP), the lowest-molecular-weight phthalate ester (PAE), is one of the most commonly detected persistent organic pollutants in the environment, but its toxic effects, especially cardiovascular developmental toxicity, are largely unknown. In this study, zebrafish embryos were exposed to sublethal concentrations of DMP from 4 to 96 hpf. Our results showed that DMP treatment induced yolk retention, pericardial edema, and swim bladder deficiency, as well as increased SV-BA distance and decreased heart rate, stroke volume, ventricular axis shortening rate and ejection fraction. In addition, oxidative stress and apoptosis were found to be highly involved in this process. The results of transcriptome sequencing and mRNA expression of related genes indicated that MAPK and calcium signaling pathways were perturbed by DMP. These findings have the potential to provide new insights into the potential developmental toxicity and cardiovascular disease risk of DMP.
中文翻译：
邻苯二甲酸二甲酯通过调节 MAPK 和钙信号通路诱导斑马鱼胚胎心血管发育毒性
邻苯二甲酸二甲酯（DMP）是分子量最低的邻苯二甲酸酯（PAE），是环境中最常检测到的持久性有机污染物之一，但其毒性作用，特别是心血管发育毒性，在很大程度上尚不清楚。在这项研究中，斑马鱼胚胎在 4 至 96 hpf 期间暴露于亚致死浓度的 DMP。我们的结果表明，DMP 治疗可引起卵黄滞留、心包水肿和鳔缺陷，以及 SV-BA 距离增加和心率、每搏输出量、心室轴缩短率和射血分数降低。此外，发现氧化应激和细胞凋亡高度参与这一过程。转录组测序和相关基因mRNA表达的结果表明MAPK和钙信号通路受到DMP的干扰。这些发现有可能为 DMP 的潜在发育毒性和心血管疾病风险提供新的见解。
更新日期：2024-03-21
中文翻译：
邻苯二甲酸二甲酯通过调节 MAPK 和钙信号通路诱导斑马鱼胚胎心血管发育毒性
邻苯二甲酸二甲酯（DMP）是分子量最低的邻苯二甲酸酯（PAE），是环境中最常检测到的持久性有机污染物之一，但其毒性作用，特别是心血管发育毒性，在很大程度上尚不清楚。在这项研究中，斑马鱼胚胎在 4 至 96 hpf 期间暴露于亚致死浓度的 DMP。我们的结果表明，DMP 治疗可引起卵黄滞留、心包水肿和鳔缺陷，以及 SV-BA 距离增加和心率、每搏输出量、心室轴缩短率和射血分数降低。此外，发现氧化应激和细胞凋亡高度参与这一过程。转录组测序和相关基因mRNA表达的结果表明MAPK和钙信号通路受到DMP的干扰。这些发现有可能为 DMP 的潜在发育毒性和心血管疾病风险提供新的见解。
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