Staphylococcus aureus (S. aureus) is a common pathogen that can cause many human diseases, such as skin infection, food poisoning, endocarditis, and sepsis. These diseases can be minor infections or life-threatening, requiring complex medical management resulting in substantial healthcare costs. Meanwhile, as the critically ignored “organ,” the intestinal microbiome greatly impacts physiological health, not only in gastrointestinal diseases but also in disorders beyond the gut. However, the correlation between S. aureus infection and intestinal microbial homeostasis is largely unknown. Here, we summarized the recent progress in understanding S. aureus infections and their interactions with the microbiome in the intestine. These summarizations will help us understand the mechanisms behind these infections and crosstalk and the challenges we are facing now, which could contribute to preventing S. aureus infections, effective treatment investigation, and vaccine development.

中文翻译：

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金黄色葡萄球菌感染和人类肠道微生物群

金黄色葡萄球菌（S. aureus）是一种常见病原体，可引起多种人类疾病，如皮肤感染、食物中毒、心内膜炎和败血症等。这些疾病可能是轻微感染或危及生命，需要复杂的医疗管理，从而导致巨额医疗费用。与此同时，作为被严重忽视的“器官”，肠道微生物组极大地影响着生理健康，不仅在胃肠道疾病中，而且在肠道以外的疾病中。然而，金黄色葡萄球菌感染与肠道微生物稳态之间的相关性在很大程度上尚不清楚。在这里，我们总结了了解金黄色葡萄球菌感染及其与肠道微生物组相互作用的最新进展。这些总结将帮助我们了解这些感染和串扰背后的机制以及我们现在面临的挑战，这可能有助于预防金黄色葡萄球菌感染、有效的治疗研究和疫苗开发。