BackgroundLiver fibrosis (LF) precipitates systemic hemodynamic alterations, however, its impact on the aorta remaining undefined.PurposeTo assess aorta hemodynamics changes during LF development in a rabbit model.Study TypeProspective, experimental.Animal ModelThirty 7‐month‐old male rabbits underwent bile duct ligation (BDL) to induce LF.Field Strength/SequenceBiweekly four‐dimensional (4D) flow imaging incorporating a 3D gradient‐echo at 3.0 T scanner for 14 weeks post‐BDL.AssessmentHistopathological exams for 2–5 rabbits were performed at each time point, following each MRI scan. LF was graded using the Metavir scale by a pathologist. 4D flow was analyzed by two radiologists using dedicated postprocessing software. They recorded 4D flow parameters at four aorta sections (aortic sinus, before and after bifurcation of aortic arch, and descending aorta).Statistical TestsThe linear mixed model; Bonferroni correction; Pearson correlation coefficient (r); receiver operating characteristic (ROC) curve; Delong test. The level of significance was set at P < 0.05.ResultsFollowing BDL, the wall shear stress (WSS) (0.23–0.32 Pa), energy loss (EL) (0.27–1.55 mW) of aorta significantly increased at the second week for each plane, peaking at the sixth week (WSS: 0.35–0.49 Pa, EL: 0.57–2.0 mW). So did the relative pressure difference (RPD) (second week: 1.67 ± 1.63 mmHg, sixth week: 2.43 ± 0.63 mmHg) in plane 2. Notably, the RPD in plane 2 at the second week displayed the highest area under ROC curve of 0.998 (specificity: 1, sensitivity: 0.967). LF were found at the second, fourth, and sixth week after BDL, with grade F2, F3, and F4, respectively. The RPD in plane 2 was most strongly correlated with the severity of LF (r = 0.86).Data ConclusionsThe occurrence of LF could increase WSS, EL, and RPD of aorta as early as the second week following BDL.Level of Evidence1Technical EfficacyStage 2

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利用磁共振成像四维流评估肝纤维化兔的主动脉血流动力学

背景肝纤维化 (LF) 会导致全身血流动力学改变，但其对主动脉的影响尚不明确。目的评估兔模型 LF 发育过程中主动脉血流动力学的变化。研究类型前瞻性、实验性。动物模型对 30 只 7 个月大的雄性兔进行胆管移植结扎 (BDL) 诱导 LF。场强/序列每两周一次四维 (4D) 血流成像，在 3.0 T 扫描仪上结合 3D 梯度回波，持续 14 周。评估 BDL 后 14 周，对 2-5 只兔子进行组织病理学检查，每次 MRI 扫描后。病理学家使用 Metavir 量表对 LF 进行分级。两名放射科医生使用专用后处理软件对 4D 血流进行了分析。他们记录了四个主动脉截面（主动脉窦、主动脉弓分叉前后以及降主动脉）的 4D 血流参数。邦费罗尼校正；皮尔逊相关系数（r）；受试者工作特征（ROC）曲线；德隆测试。显着性水平设定为磷< 0.05. 结果BDL 后，主动脉壁剪应力 (WSS) (0.23–0.32 Pa)、能量损失 (EL) (0.27–1.55 mW) 在每个平面的第二周显着增加，在第六周达到峰值 (WSS) ：0.35–0.49 Pa，EL：0.57–2.0 mW）。平面 2 中的相对压力差 (RPD)（第二周：1.67 ± 1.63 mmHg，第六周：2.43 ± 0.63 mmHg）也是如此。值得注意的是，第二周平面 2 的 RPD 显示 ROC 曲线下面积最高，为 0.998 （特异性：1，灵敏度：0.967）。 BDL后第2周、第4周和第6周发现LF，等级分别为F2、F3和F4。平面 2 中的 RPD 与 LF 的严重程度相关性最强（r= 0.86）。数据结论 LF的发生最早可在BDL后第二周增加主动脉的WSS、EL和RPD。证据级别1技术功效阶段2