Noise-induced hearing loss (NIHL) is a highly prevalent form of sensorineural hearing damage that has significant negative effects on individuals of all ages, and there are no effective drugs approved by the Food and Drug Administration. In this study, we unveil the potential of superparamagnetic iron oxide nanoparticle assembly (SPIOCA) to reshape the dysbiosis of gut microbiota for treating NIHL. This modulation inhibits intestinal inflammation and oxidative stress responses, protecting the integrity of the intestinal barrier. Consequently, it reduces the transportation of pathogens and inflammatory factors from the bloodstream to the cochlea. Additionally, gut microbiota modulated SPIOCA-induced metabolic reprogramming in the gut-inner ear axis mainly depends on the regulation of the sphingolipid metabolic pathway, which further contributes to the restoration of hearing function. Our study confirms the role of the microbiota-gut-inner ear axis in NIHL and provides a novel alternative for the treatment of NIHL and other microbiota dysbiosis-related diseases.

中文翻译：

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超顺磁性氧化铁纳米颗粒调节微生物群-肠道-内耳轴以保护听力

噪声性听力损失 (NIHL) 是一种非常普遍的感音神经性听力损伤，对所有年龄段的个人都有显着的负面影响，而且美国食品和药物管理局还没有批准有效的药物。在这项研究中，我们揭示了超顺磁性氧化铁纳米粒子组装体 (SPIOCA) 重塑肠道微生物群失调以治疗 NIHL 的潜力。这种调节抑制肠道炎症和氧化应激反应，保护肠道屏障的完整性。因此，它减少了病原体和炎症因子从血液到耳蜗的运输。此外，肠道微生物群调节SPIOCA诱导的肠道-内耳轴代谢重编程主要依赖于鞘脂代谢途径的调节，这进一步有助于听力功能的恢复。我们的研究证实了微生物群-肠道-内耳轴在 NIHL 中的作用，并为治疗 NIHL 和其他微生物群失调相关疾病提供了一种新的替代方案。