Objective In this post hoc analysis of a previously published study, we compared cytokines and adipokine levels in women and men with psoriatic arthritis (PsA) at baseline (BL) and 6 months (M6) following a weight loss intervention. Methods Patients with PsA (n=41) between 25 and 75 years of age, with body mass index (BMI)≥33 kg/m2 were included in a weight loss intervention with a very low energy diet (VLED) for 12 or 16 weeks depending on BL BMI<40 or ≥40 kg/m2. As controls (n=39), obese individuals, already planned for VLED treatment were recruited and matched for sex, age and weight to the patients with PsA. Cytokines and adipokines were measured at BL and M6. Results At BL, serum levels of interleukin (IL)-23, leptin and high molecular weight-adiponectin were higher in women with PsA compared with men, whereas serum levels of interferon (IFN)-γ, IL-12/IL-23 p40 and IL-13 were significantly lower in women. Serum IL-23 was significantly reduced at M6 compared with BL in women but not in men with PsA. In women with PsA, the reduction in IL-23 at M6, ∆IL-23, were positively correlated with ∆Disease Activity Score 28 C reactive protein (CRP) (Spearman’s correlation (rS)=0.486, p=0.016), ∆CRP (rS=0.468, p=0.021), ∆leptin (rS=0.683, p<0.001) and negatively correlated with ∆total-adiponectin (rS=−0.433, p=0.035). Also in women, ∆Disease Activity in Psoriatic Arthritis was positively correlated with ∆tumour necrosis factor-α (rS=0.417, p=0.034), ∆IL-1β (rS=0.550, p=0.034), ∆IFN-γ (rS=0.414, p=0.035) and ∆leptin (rS=0.410, p=0.038). None of these correlations were significant in men with PsA. Conclusions Women and men with PsA differed with regard to serum levels of cytokines and adipokines before and after weight loss.

中文翻译：

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肥胖 PsA 患者和接受减肥干预的对照组细胞因子和脂肪因子的性别差异

目的 在对先前发表的研究进行事后分析时，我们比较了患有银屑病关节炎 (PsA) 的女性和男性在基线 (BL) 和减肥干预后 6 个月 (M6) 时的细胞因子和脂肪因子水平。方法 年龄在 25 至 75 岁之间、体重指数 (BMI) ≥ 33 kg/m2 的 PsA 患者 (n=41) 接受为期 12 或 16 周的极低能量饮食 (VLED) 减肥干预取决于 BL BMI<40 或 ≥40 kg/m2。作为对照 (n=39)，招募已计划接受 VLED 治疗的肥胖个体，并将其性别、年龄和体重与 PsA 患者进行匹配。在 BL 和 M6 处测量细胞因子和脂肪因子。结果 BL 时，女性 PsA 患者的血清白细胞介素 (IL)-23、瘦素和高分子量脂联素水平高于男性，而干扰素 (IFN)-γ、IL-12/IL-23 p40 血清水平较高女性中 IL-13 和 IL-13 显着降低。与 BL 相比，患有 PsA 的女性患者的血清 IL-23 在 M6 时显着降低，但男性患者的血清 IL-23 没有显着降低。在患有 PsA 的女性中，M6 时 IL-23 的减少（ΔIL-23）与 Δ疾病活动评分 28 C 反应蛋白 (CRP) 呈正相关（Spearman 相关性 (rS)=0.486，p=0.016）、ΔCRP （rS=0.468，p=0.021）、Δ瘦素（rS=0.683，p<0.001）并与Δ总脂联素呈负相关（rS=−0.433，p=0.035）。同样在女性中，Δ银屑病关节炎疾病活动度与Δ肿瘤坏死因子-α (rS=0.417，p=0.034)、ΔIL-1β (rS=0.550，p=0.034)、ΔIFN-γ (rS =0.414，p=0.035）和 Δ瘦素（rS=0.410，p=0.038）。这些相关性在患有银屑病关节炎的男性中均不显着。结论 患有 PsA 的女性和男性在减肥前后的细胞因子和脂肪因子血清水平存在差异。