Primary cilia are static microtubule-based structures protruding from the cell surface and present on most vertebrate cells. The appropriate localization of phospholipids is essential for cilia formation and stability. INPP5E is a cilia-localized inositol 5-phosphatase; its deletion alters the phosphoinositide composition in the ciliary membrane, disrupting ciliary function.

中文翻译：

---

INPP5E 调节 RPE1 细胞纤毛上磷脂的分布

初级纤毛是从细胞表面突出的基于静态微管的结构，存在于大多数脊椎动物细胞上。磷脂的适当定位对于纤毛的形成和稳定性至关重要。 INPP5E 是一种纤毛定位的肌醇 5-磷酸酶；它的缺失改变了睫状膜中磷酸肌醇的组成，破坏了睫状体功能。