We have developed a photocatalyst/base/metal-free, visible-light-driven three-component annulation protocol to access fully substituted 2-iminothiazolidin-4-one derivatives from isothiocyanates, amines, and aryl diazoacetates using a low-energy white light source at room temperature in open air. The [2 + 2 + 1] reaction undergoes successive C–N/C–S bond formation in one pot. This transformation proceeds under extremely mild conditions with a good yield and a good functional group tolerance. Mechanistic studies showed that the reaction involves the formation of free carbene intermediates from aryl diazoacetates under visible light irradiation.

中文翻译：

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可见光驱动的三组分成环，无需光催化剂即可合成高功能化的 2-亚氨基噻唑烷-4-酮

我们开发了一种无光催化剂/碱/金属、可见光驱动的三组分成环方案，使用低能白光源从异硫氰酸酯、胺和重氮乙酸芳基酯中获得完全取代的 2-亚氨基噻唑烷-4-酮衍生物在室温下露天。 [2 + 2 + 1] 反应在一锅中连续形成 C-N/C-S 键。该转化在极其温和的条件下进行，具有良好的产率和良好的官能团耐受性。机理研究表明，该反应涉及在可见光照射下由重氮乙酸芳基酯形成游离卡宾中间体。