The anticancer drugs -diamminedichloridoplatinum (II) (cisplatin) and oxaliplatin are commonly used to treat patients with a number of cancers including gastrointestinal cancer. While platinum drugs have succeeded in prolonging overall progression-free survival of gastrointestinal cancer patients, treatment with platinum-based chemotherapeutics can cause resistance, and platinum-chemoresistance poses one of the main challenges to gastrointestinal cancer therapy and overall use of platinum-based chemotherapy. In addition to their interactions with DNA, Pt-chemotherapeutics commonly interact with cellular RNA. This manuscript explores the speciation of cisplatin and oxaliplatin, describes their interaction with DNA and RNA, and discusses similarities and differences which cause the different physiological responses of long non-coding RNAs upon treatment with platinum reagents. It explores the aberrant expression of long non-coding RNAs in gastrointestinal cancer including oral cavity cancer, esophageal cancer, gastric cancer, and colorectal cancer. Here we identify several long non-coding RNAs which are aberrantly expressed in platinum-resistant cell lines of gastrointestinal cancers. Although different gastrointestinal cancer cell lines are tested, increased or decreased aberrant expression compared to normal cells is found for the same long non-coding RNAs, suggesting that gene expression and cellular pathways are changed in a similar manner. Indubitably, further understanding of these phenomena will be beneficial to evaluate if these behaviors can be exploited to develop strategies for use in future therapeutic strategies for treatment of gastrointestinal cancer patients.

中文翻译：

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胃肠癌细胞对铂的耐药性及其与长非编码RNA异常表达的关系

抗癌药物二氯二氨铂 (II)（顺铂）和奥沙利铂通常用于治疗包括胃肠癌在内的多种癌症患者。虽然铂类药物成功地延长了胃肠道癌症患者的总体无进展生存期，但铂类化疗药物治疗可能会引起耐药性，而铂类化疗耐药性是胃肠道癌症治疗和铂类化疗总体使用的主要挑战之一。除了与 DNA 相互作用外，铂化疗药物通常还与细胞 RNA 相互作用。本手稿探讨了顺铂和奥沙利铂的形态，描述了它们与 DNA 和 RNA 的相互作用，并讨论了导致长非编码 RNA 在用铂试剂处理后产生不同生理反应的相似点和差异。它探讨了长链非编码RNA在胃肠道癌症（包括口腔癌、食道癌、胃癌和结直肠癌）中的异常表达。在这里，我们鉴定了几种在胃肠癌铂耐药细胞系中异常表达的长非编码RNA。尽管测试了不同的胃肠癌细胞系，但与正常细胞相比，发现相同的长非编码RNA的异常表达增加或减少，这表明基因表达和细胞途径以类似的方式改变。毫无疑问，对这些现象的进一步了解将有助于评估是否可以利用这些行为来制定用于未来胃肠道癌症患者治疗策略的策略。