Electrocorticogram (ECoG): Engineering Approaches and Clinical Challenges for Translational Medicine,Advanced Materials Technologies

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Electrocorticogram (ECoG): Engineering Approaches and Clinical Challenges for Translational Medicine
Advanced Materials Technologies ( IF 6.4 ) Pub Date : 2024-03-21 , DOI: 10.1002/admt.202301692
Hyunmin Moon _{1,

2} , Jii Kwon ₃ , Jonghee Eun ₄ , Chun Kee Chung _{3,

5} , June Sic Kim ₆ , Namsun Chou ₄ , Sohee Kim _{1,

7}

Affiliation

Electrocorticogram (ECoG) is an electrophysiological signal that results from the summation of neuronal activity near the cortical surface. To record ECoG signals, the scalp and skull are surgically opened and electrodes are placed on the cortical surface, either epidurally or subdurally. Owing to its improved spatiotemporal resolution and signal quality compared with electroencephalography, it is widely used to diagnose and treat neurological disorders in clinical settings for several decades, despite the invasiveness of ECoG. Recently, ECoG is applied in research to explore brain functions and connectivity, brain-computer interfaces, and brain-machine interfaces. In addition to the need for ECoG in neuroscience research, ECoG devices have advanced in terms of materials, fabrication, and function to overcome the limitations of commercially available ECoG arrays. Here, the conventional use of ECoG in clinical medicine, the new applications of ECoG in basic neuroscience research, and the future challenges in translating recent developments in ECoG devices for clinical use are described.

中文翻译：

皮质电图 (ECoG)：转化医学的工程方法和临床挑战

皮质电图 (ECoG) 是一种电生理信号，由皮质表面附近神经元活动的总和产生。为了记录 ECoG 信号，需要通过手术打开头皮和颅骨，并将电极放置在硬膜外或硬膜下的皮质表面上。与脑电图相比，由于其时空分辨率和信号质量有所提高，尽管 ECoG 具有侵入性，但几十年来它在临床环境中广泛用于诊断和治疗神经系统疾病。最近，ECoG 被应用于探索大脑功能和连接、脑机接口和脑机接口的研究。除了神经科学研究中对 ECoG 的需求之外，ECoG 设备在材料、制造和功能方面也取得了进步，以克服商用 ECoG 阵列的局限性。在此，描述了 ECoG 在临床医学中的常规应用、ECoG 在基础神经科学研究中的新应用，以及将 ECoG 设备的最新发展转化为临床应用的未来挑战。

更新日期：2024-03-21

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