Correction: Physiologically based radiopharmacokinetic (PBRPK) modeling to simulate and analyze radiopharmaceutical therapies: studies of non-linearities, multi-bolus injections, and albumin binding,EJNMMI Radiopharmacy and Chemistry

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Correction: Physiologically based radiopharmacokinetic (PBRPK) modeling to simulate and analyze radiopharmaceutical therapies: studies of non-linearities, multi-bolus injections, and albumin binding
EJNMMI Radiopharmacy and Chemistry Pub Date : 2024-03-19 , DOI: 10.1186/s41181-024-00251-5
Ali Fele‑Paranj , Babak Saboury , Carlos Uribe , Arman Rahmim

Correction: EJNMMI Radiopharmacy and Chemistry (2024) 9:6 https://doi.org/10.1186/s41181-023-00236-w

In the original publication of the article, inaccuracies were identified in Figures 3 and 7 due to an incorrect application of S values in the dose calculations. The S values, which should vary with tumor volume to accurately represent dose distribution, were mistakenly kept constant.

Upon review, the authors have corrected this error and recalculated the doses with varying 1/s values as they should proportionally change with tumor sizes (volumes). Below is a Table 1 of the corrected S values and their corresponding tumor volumes:

Table 1 Corrected S values and corresponding tumor volumes

Full size table

These errors also affected figures 3 and 7. The incorrect and correct figures are shown in this correction article. The corrected figures show that with increasing volumes the distributions are minimally altered; all other figures and conclusions remain intact.

Incorrect figure 3

Incorrect figure 7

Correct figure 3

Correct figure 7

Authors and Affiliations

School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada
Ali Fele‑Paranj & Arman Rahmim
Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada
Ali Fele‑Paranj, Carlos Uribe & Arman Rahmim
Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA
Babak Saboury
Department of Functional Imaging, BC Cancer, Vancouver, BC, Canada
Carlos Uribe
Department of Radiology, University of British Columbia, Vancouver, BC, Canada
Carlos Uribe & Arman Rahmim

Authors

Ali Fele‑ParanjView author publications
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Babak SabouryView author publications
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Carlos UribeView author publications
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Arman RahmimView author publications
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Corresponding author

Correspondence to Arman Rahmim.

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Fele‑Paranj, A., Saboury, B., Uribe, C. et al. Correction: Physiologically based radiopharmacokinetic (PBRPK) modeling to simulate and analyze radiopharmaceutical therapies: studies of non-linearities, multi-bolus injections, and albumin binding. EJNMMI radiopharm. chem. 9, 22 (2024). https://doi.org/10.1186/s41181-024-00251-5

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Published: 19 March 2024
DOI: https://doi.org/10.1186/s41181-024-00251-5

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中文翻译：

修正：基于生理学的放射性药物动力学 (PBRPK) 模型来模拟和分析放射性药物治疗：非线性、多次推注和白蛋白结合的研究

更正：EJNMMI 放射性药物与化学 (2024) 9:6 https://doi.org/10.1186/s41181-023-00236-w

在该文章的原始出版物中，由于剂量计算中 S 值的应用不正确，图 3 和图 7 中发现了不准确之处。 S 值应随肿瘤体积变化以准确表示剂量分布，但错误地保持恒定。

经过审查，作者纠正了这个错误，并以不同的 1/s 值重新计算剂量，因为它们应该随肿瘤大小（体积）成比例地变化。下面是校正后的 S 值及其对应的肿瘤体积的表 1：

表1 校正后的S值和对应的肿瘤体积

全尺寸桌子

这些错误也影响了图 3 和图 7。错误和正确的图显示在这篇更正文章中。修正后的数据显示，随着交易量的增加，分布变化很小；所有其他数据和结论保持不变。

错误的图3

错误的图7

正确的图3

正确的图7

作者和单位

不列颠哥伦比亚大学生物医学工程学院，加拿大不列颠哥伦比亚省温哥华
阿里·费莱·帕兰吉 & 阿曼·拉赫米姆
加拿大不列颠哥伦比亚省温哥华，不列颠哥伦比亚省癌症研究所综合肿瘤学系
阿里·费莱·帕兰吉、卡洛斯·乌里韦和阿曼·拉赫米姆
美国国立卫生研究院临床中心放射学和影像科学系，美国马里兰州贝塞斯达
巴巴克·萨布里
功能影像科，BC 癌症中心，温哥华，不列颠哥伦比亚省，加拿大
卡洛斯·乌里韦
加拿大不列颠哥伦比亚省温哥华市不列颠哥伦比亚大学放射科
卡洛斯·乌里韦 & 阿曼·拉姆

作者

Ali Fele‑Paranj查看作者出版物
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Babak Saboury查看作者出版物
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卡洛斯·乌里韦查看作者出版物
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Arman Rahmim查看作者出版物
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通讯作者

通讯作者：Arman Rahmim。

出版商备注

施普林格·自然对于已出版的地图和机构隶属关系中的管辖权主张保持中立。

开放获取本文根据知识共享署名 4.0 国际许可证获得许可，该许可证允许以任何媒介或格式使用、共享、改编、分发和复制，只要您对原作者和来源给予适当的认可，提供知识共享许可的链接，并指出是否进行了更改。本文中的图像或其他第三方材料包含在文章的知识共享许可中，除非材料的出处中另有说明。如果文章的知识共享许可中未包含材料，并且您的预期用途不受法律法规允许或超出了允许的用途，则您需要直接获得版权所有者的许可。要查看此许可证的副本，请访问 http://creativecommons.org/licenses/by/4.0/。

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引用这篇文章

Fele-Paranj, A.、Saboury, B.、Uribe, C.等人。修正：基于生理学的放射性药物动力学 (PBRPK) 模型来模拟和分析放射性药物疗法：非线性、多次推注注射和白蛋白结合的研究。EJNMMI 放射制药。化学。 9 , 22 (2024)。 https://doi.org/10.1186/s41181-024-00251-5

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