SARS-CoV-2 infection on pregnant women was the subject of many questions since the COVID-19 pandemic. We aim to assess maternal and neonatal outcomes of SARS-CoV-2 infection contracted during 2nd and 3rd trimesters of pregnancy during the first two COVID-19 waves across a prospective French multicenter cohort study. Patients were included between April 2020 and January 2021 in 10 maternity hospitals in Paris area with two groups (i) pregnant women with a positive SARS-CoV-2 nasopharyngeal RT-PCR between [14WG; 37WG[(symptomatic infection), (ii) pregnant women with a negative serology (or equivocal) at delivery and without a positive SARS-CoV-2 nasopharyngeal RT-PCR at any time during pregnancy (G2 group) 2410 pregnant women were included, of whom 310 had a positive SARS-CoV-2 nasopharyngeal RT-PCR and 217 between [14WG; 37WG[. Most infections occurred between 28 and 37 weeks of gestation (56 %). Most patients could be managed as outpatients, while 23 % had to be hospitalized. Among women with a positive RT-PCR, multiparous women were over-represented (OR = 2.45[1.52;3.87]); were more likely to deliver before 37 weeks of gestation (OR = 2.19[1.44;3.24]) and overall cesarean deliveries were significantly increased (OR = 1.53[1.09;2.13]). This study highlights the maternal, obstetrical, and neonatal burden associated with SARS-CoV-2 infections during the first two pandemic waves before availability of vaccines. NCT04355234 (registration date: 21/04/2020)

中文翻译：

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法国前瞻性多中心队列研究 COVIPREG 在前两波 COVID-19 浪潮中的孕产妇和新生儿结局

自 COVID-19 大流行以来，孕妇感染 SARS-CoV-2 一直是许多问题的主题。我们的目标是在一项法国前瞻性多中心队列研究中，评估前两波 COVID-19 浪潮期间妊娠第二期和第三期期间感染 SARS-CoV-2 的孕产妇和新生儿结局。 2020 年 4 月至 2021 年 1 月期间，巴黎地区 10 家妇产医院的患者被纳入两组：(i) SARS-CoV-2 鼻咽 RT-PCR 呈阳性的孕妇 [14WG； 37WG[（有症状感染），(ii) 分娩时血清学呈阴性（或模棱两可）且在怀孕期间任何时间 SARS-CoV-2 鼻咽 RT-PCR 均未呈阳性的孕妇（G2 组）纳入了 2410 名孕妇，其中 310 人的 SARS-CoV-2 鼻咽 RT-PCR 呈阳性，217 人在 [14WG； 37WG[。大多数感染发生在妊娠 28 至 37 周之间（56%）。大多数患者可以门诊治疗，23%的患者必须住院治疗。在 RT-PCR 呈阳性的女性中，经产女性比例过高 (OR = 2.45[1.52;3.87])；更有可能在妊娠 37 周之前分娩 (OR = 2.19[1.44;3.24])，并且剖宫产总数显着增加 (OR = 1.53[1.09;2.13])。这项研究强调了在疫苗问世之前的前两波大流行期间与 SARS-CoV-2 感染相关的孕产妇、产科和新生儿负担。 NCT04355234（注册日期：2020年4月21日）