Exploiting synthetic biology platforms for enhanced biosynthesis of natural products in Yarrowia lipolytica,Bioresource Technology

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Exploiting synthetic biology platforms for enhanced biosynthesis of natural products in Yarrowia lipolytica
Bioresource Technology ( IF 9.7 ) Pub Date : 2024-03-19 , DOI: 10.1016/j.biortech.2024.130614
Dahai Jiang ₁ , Manqi Yang ₁ , Kai Chen ₁ , Wenxuan Jiang ₁ , Liangliang Zhang ₁ , Xiao-Jun Ji ₂ , Jianchun Jiang ₃ , Liming Lu ₁

Affiliation

With the rapid development of synthetic biology, researchers can design, modify, or even synthesize microorganisms , and microorganisms endowed with unnatural functions can be considered “artificial life” and facilitate the development of functional products. Based on this concept, researchers can solve critical problems related to the insufficient supply of natural products, such as low yields, long production cycles, and cumbersome procedures. Due to its superior performance and unique physiological and biochemical characteristics, is a favorable chassis cell used for green biomanufacturing by numerous researchers. This paper mainly reviews the development of synthetic biology techniques for and summarizes the recent research progress on the synthesis of natural products in . This review will promote the continued innovative development of by providing theoretical guidance for research on the biosynthesis of natural products.

中文翻译：

利用合成生物学平台增强解脂耶氏酵母天然产物的生物合成

随着合成生物学的快速发展，研究人员可以设计、改造甚至合成微生物，赋予非自然功能的微生物可以被认为是“人工生命”，有利于功能产品的开发。基于这一理念，研究人员可以解决天然产物供应不足的产量低、生产周期长、程序繁琐等关键问题。由于其优越的性能和独特的生理生化特性，是众多研究者用于绿色生物制造的有利底盘细胞。本文主要回顾了合成生物学技术的发展，总结了近年来天然产物合成的研究进展。该综述将为天然产物生物合成研究提供理论指导，促进其持续创新发展。

更新日期：2024-03-19

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