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Metabolic profiles outperform the microbiota in assessing the response of vaginal microenvironments to the changed state of HPV infection
npj Biofilms and Microbiomes ( IF 9.2 ) Pub Date : 2024-03-20 , DOI: 10.1038/s41522-024-00500-0
Wenkui Dai , Hui Du , Qian Zhou , Sumei Li , Yinan Wang , Jun Hou , Chunlei Guo , Qing Yang , Changzhong Li , Shouxia Xie , Shuai Cheng Li , Ruifang Wu

There is a deficiency in population-based studies investigating the impact of HPV infection on vaginal microenvironment, which influences the risk of persistent HPV infection. This prospective study aimed to unravel the dynamics of vaginal microbiota (VM) and vaginal metabolome in reaction to the changed state of HPV infection. Our results propose that the vaginal metabolome may be a superior indicator to VM when assessing the impact of altered HPV state on the vaginal microenvironment.



中文翻译:

在评估阴道微环境对 HPV 感染状态变化的反应时,代谢特征优于微生物群

基于人群的研究缺乏调查 HPV 感染对阴道微环境的影响,而阴道微环境会影响 HPV 持续感染的风险。这项前瞻性研究旨在揭示阴道微生物群 (VM) 和阴道代谢组对 HPV 感染状态变化的反应动态。我们的结果表明,在评估 HPV 状态改变对阴道微环境的影响时,阴道代谢组可能是优于 VM 的指标。

更新日期:2024-03-20
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