Biodegradable polymers play a crucial role in the development of materials for biomedical applications. This study investigates the enzymatic biodegradation, bioactivity, and cytotoxicity of poly(butylene succinate‐dilinoleic succinate) (PBS‐DLS) copolymers modified with poly(ethylene glycol) (PEG). Two copolymer variations with different segmental compositions (70 wt.% and 60 wt.% of hard segments) are synthesized. After modifying the copolymers with PEG, the presence of a lipase catalyst accelerated degradation after 20 days, evidenced by reduced residual content. Gel permeation chromatography analysis showed up to 40% decrease in molecular weight, while gravimetric analysis indicated a mass loss of up to 10%. Morphological examination revealed that the enzymatic breakdown, facilitated by hydrolase activity (boosted by the presence of PEG), resulted in surface erosion, holes, and changes in spherulitic morphology. Bioactivity studies demonstrated the formation of biomimetic calcium/phosphate (Ca/P) crystals. Copolymers with higher crystallinity (70 wt.% hard segments) favored tricalcium phosphate‐like crystal formation, while those with lower crystallinity (60 wt.% hard segments) are more susceptible to hydroxyapatite precipitation. In vitro cytotoxicity tests exhibited excellent cell viability and attachment for all copolymers. The ability to control degradation through PEG modification, along with their bioactivity and cell compatibility, positions them as promising candidates for diverse biomedical applications.

中文翻译：

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通过掺入 PEG 提高 PBS-DLS 共聚物的生物降解和生物活性

可生物降解聚合物在生物医学应用材料的开发中发挥着至关重要的作用。本研究研究了聚乙二醇（PEG）修饰的聚（琥珀酸丁二酯-二亚油酸琥珀酸酯）（PBS-DLS）共聚物的酶促生物降解、生物活性和细胞毒性。合成了具有不同链段组成（70 wt.% 和 60 wt.% 硬链段）的两种共聚物变体。用 PEG 改性共聚物后，脂肪酶催化剂的存在在 20 天后加速了降解，残留含量降低证明了这一点。凝胶渗透色谱分析显示分子量下降高达 40%，而重量分析表明质量损失高达 10%。形态学检查表明，水解酶活性（PEG 的存在增强）促进酶分解，导致表面侵蚀、孔洞和球晶形态的变化。生物活性研究证明了仿生钙/磷酸盐 (Ca/P) 晶体的形成。结晶度较高的共聚物（70 wt.% 硬段）有利于磷酸三钙晶体的形成，而结晶度较低（60 wt.% 硬段）的共聚物更容易发生羟基磷灰石沉淀。体外细胞毒性测试显示所有共聚物均具有出色的细胞活力和附着力。通过 PEG 修饰控制降解的能力，以及它们的生物活性和细胞相容性，使它们成为各种生物医学应用的有希望的候选者。