Neuroinflammation is a key feature of Alzheimer’s disease (AD). In this work, analysis of single- cell RNA-sequencing (scRNA-seq) data obtained from the brain of patients with AD provides evidence supporting a switch from an innate to an adaptative immune response during tauopathy progression, with both disease-associated microglia (DAM) and CD8+ T cells becoming more frequent at advanced Braak stages.

中文翻译：

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阿尔茨海默病患者大脑中先天性免疫反应向适应性免疫反应的转变与 tau 蛋白病进展相关

神经炎症是阿尔茨海默病（AD）的一个关键特征。在这项工作中，对从 AD 患者大脑中获得的单细胞 RNA 测序 (scRNA-seq) 数据进行分析，提供了支持在 tau 蛋白病进展过程中从先天性免疫反应转变为适应性免疫反应的证据，与疾病相关的小胶质细胞。 DAM）和 CD8+ T 细胞在 Braak 晚期阶段变得更加频繁。