Targeted covalent inhibitors (TCIs) can react irreversibly with lysine in kinases and other proteins. Small molecule TCIs can have both broad or specific lysine targeting whereas peptide- and protein-based TCIs were shown to provide high target specificity for lysines in shallow protein surfaces.

中文翻译：

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用赖氨酸喜结连理

靶向共价抑制剂 (TCIs) 可以与激酶和其他蛋白质中的赖氨酸发生不可逆反应。小分子 TCI 可以具有广泛或特异性的赖氨酸靶向性，而基于肽和蛋白质的 TCI 可以为浅蛋白质表面的赖氨酸提供高靶特异性。