AimsThis study aimed to investigate the resting‐state functional connectivity and topologic characteristics of brain networks in patients with diabetic optic neuropathy (DON).MethodsResting‐state functional magnetic resonance imaging scans were performed on 23 patients and 41 healthy control (HC) subjects. We used independent component analysis and graph theoretical analysis to determine the topologic characteristics of the brain and as well as functional network connectivity (FNC) and topologic properties of brain networks.ResultsCompared with HCs, patients with DON showed altered global characteristics. At the nodal level, the DON group had fewer nodal degrees in the thalamus and insula, and a greater number in the right rolandic operculum, right postcentral gyrus, and right superior temporal gyrus. In the internetwork comparison, DON patients showed significantly increased FNC between the left frontoparietal network (FPN‐L) and ventral attention network (VAN). Additionally, in the intranetwork comparison, connectivity between the left medial superior frontal gyrus (MSFG) of the default network (DMN) and left putamen of auditory network was decreased in the DON group.ConclusionDON patients altered node properties and connectivity in the DMN, auditory network, FPN‐L, and VAN. These results provide evidence of the involvement of specific brain networks in the pathophysiology of DON.

中文翻译：

---

糖尿病视神经病变的图论分析和独立成分分析：静息态功能磁共振成像研究

目的本研究旨在调查糖尿病视神经病变 (DON) 患者的静息态功能连接和脑网络拓扑特征。方法对 23 名患者和 41 名健康对照 (HC) 受试者进行静息态功能磁共振成像扫描。我们使用独立成分分析和图论分析来确定大脑的拓扑特征以及大脑网络的功能网络连接（FNC）和拓扑特性。结果与HCs相比，DON患者表现出改变的整体特征。在淋巴结水平，DON组丘脑和岛叶的淋巴结度数较少，而右侧沟盖、右侧中央后回和右侧颞上回的淋巴结度数较多。在网络比较中，DON 患者的左额顶网络 (FPN-L) 和腹侧注意网络 (VAN) 之间的 FNC 显着增加。此外，在网络内比较中，DON组中默认网络（DMN）的左侧内侧额上回（MSFG）与听觉网络的左侧壳核之间的连接性降低。结论DON患者改变了DMN、听觉网络中的节点属性和连接性。网络、FPN-L 和 VAN。这些结果提供了特定脑网络参与 DON 病理生理学的证据。