BackgroundDue to the rarity of cerebral venous thrombosis (CVT), performing high-quality scientific research in this field is challenging. Providing answers to unresolved research questions will improve prevention, diagnosis, and treatment, and ultimately translate to a better outcome of patients with CVT. We present an international research agenda, in which the most important research questions in the field of CVT are prioritized.AimsThis research agenda has three distinct goals: (1) To provide inspiration and focus to research on CVT for the coming years; (2) To reinforce international collaboration; and (3) To facilitate the acquisition of research funding.Summary of reviewThis international research agenda is the result of a research summit organized by the International Cerebral Venous Thrombosis Consortium in Amsterdam, the Netherlands in June 2023. The summit brought together 45 participants from 15 countries including clinical researchers from various disciplines, patients who previously suffered from CVT, and delegates from industry and non-profit funding organizations. The research agenda is categorized into six pre-specified themes: (1) Epidemiology and clinical features; (2) Life after CVT; (3) Neuroimaging and diagnosis; (4) Pathophysiology; (5) Medical treatment; and (6) Endovascular Treatment. For each theme, we present two to four research questions, followed by a brief substantiation per question. The research questions were prioritized by the participants of the summit through consensus discussion.ConclusionsThis international research agenda provides an overview of the most burning research questions on CVT. Answering these questions will advance our understanding and management of CVT, which will ultimately lead to improved outcomes for CVT patients worldwide.

中文翻译：

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减轻脑静脉血栓形成的全球负担：国际研究议程

背景由于脑静脉血栓（CVT）的罕见性，在该领域进行高质量的科学研究具有挑战性。为未解决的研究问题提供答案将改善预防、诊断和治疗，并最终为 CVT 患者带来更好的结果。我们提出了一个国际研究议程，其中优先考虑了 CVT 领域最重要的研究问题。 目的 该研究议程具有三个不同的目标：（1）为未来几年的 CVT 研究提供灵感和重点； （二）加强国际合作； (3) 促进研究经费的获取。 审查摘要本国际研究议程是国际脑静脉血栓协会于 2023 年 6 月在荷兰阿姆斯特丹组织的研究峰会的成果。该峰会汇集了来自 15 个国家的 45 名与会者各国的代表包括来自不同学科的临床研究人员、曾患有 CVT 的患者以及来自行业和非营利资助组织的代表。研究议程分为六个预先指定的主题：（1）流行病学和临床特征； (2) CVT后的寿命； (3) 神经影像与诊断； (4)病理生理学； （五）医疗； (6) 血管内治疗。对于每个主题，我们提出两到四个研究问题，然后对每个问题进行简短的论证。峰会参与者通过共识讨论对研究问题进行了优先排序。结论本国际研究议程概述了 CVT 最紧迫的研究问题。回答这些问题将增进我们对 CVT 的理解和管理，最终改善全世界 CVT 患者的治疗结果。