Bone traumatic injuries, enduring a prolonged healing process since it involves a series of bio events, becomes gradually challenging with increasing aging population. The integration of a home-based therapy strategy with emerging microelectronic technology holds promise for optimizing the whole long-term healing process of bone defect. Given the bioelectric properties of bone, utilizing biomedical electronics to providing external electric field (EF) is preferred for physical therapy strategies. Our study provides a wireless implantable bone-electronic interface (IBEI) based on ultrasonic-driven battery-free piezoelectric technology. The IBEI without percutaneous leads can effectively complete the process of converting ultrasonic signals into electric signals and finally into biological signals for bone repair. This system is miniatured, battery-free, wireless, controllable, biocomfortable and biosafe with high osteogenic efficiency. For the underlying mechanism, the EF can activate multicellular synergistic osteogenesis and up-regulate the Ca/CaMKIIα/CREB signal pathway in osteogenesis effector cells. The IBEI aligns with the future trajectory of home-based medicine, presenting a commendable therapy pattern for doctor-patient collaboration and offering a novel perspective in the realm of physical therapy.

中文翻译：

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用于骨再生家庭治疗策略的自供电、植入式骨电子接口

骨外伤由于涉及一系列生物事件而需要经历漫长的愈合过程，随着人口老龄化的加剧，骨外伤逐渐变得具有挑战性。家庭治疗策略与新兴微电子技术的结合有望优化骨缺损的整个长期愈合过程。鉴于骨骼的生物电特性，利用生物医学电子学提供外部电场（EF）是物理治疗策略的首选。我们的研究提供了一种基于超声波驱动的无电池压电技术的无线植入式骨电子接口（IBEI）。无需经皮导线的IBEI可以有效地完成将超声波信号转换为电信号，最终转换为生物信号进行骨修复的过程。该系统微型、无电池、无线、可控、生物舒适、生物安全，成骨效率高。其潜在机制是，EF可以激活多细胞协同成骨并上调成骨效应细胞中的Ca/CaMKIIα/CREB信号通路。IBEI 符合家庭医学的未来发展轨迹，为医患合作提供了值得称赞的治疗模式，并为物理治疗领域提供了新颖的视角。