is a thermophilic and facultatively anaerobic microbe, which is emerging as one of the most promising thermophilic model organisms for metabolic engineering. The use of thermophilic microorganisms for industrial bioprocesses provides the advantages of increased reaction rates and reduced cooling costs for bioreactors compared to their mesophilic counterparts. Moreover, it enables starch or lignocellulose degradation and fermentation to occur at the same temperature in a Simultaneous Saccharification and Fermentation (SSF) or Consolidated Bioprocessing (CBP) approach. Its natural hemicellulolytic capabilities and its ability to convert CO to metabolic energy make . a potentially attractive host for bio-based processes. It can effectively degrade hemicellulose due to a number of hydrolytic enzymes, carbohydrate transporters, and regulatory elements coded from a genomic cluster named Hemicellulose Utilization (HUS) locus. The growing availability of effective genetic engineering tools in further starts to open up its potential as a versatile thermophilic cell factory. A number of strain engineering examples showcasing the potential of as a microbial chassis for the production of bulk and fine chemicals are presented along with current research bottlenecks. Ultimately, this review provides a holistic overview of the distinct metabolic characteristics of and discusses research focused on expanding the native metabolic boundaries for the development of industrially relevant strains.

中文翻译：

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热葡萄糖副杆菌作为新兴的嗜热细胞工厂

是一种嗜热兼性厌氧微生物，正在成为代谢工程最有前途的嗜热模型生物之一。与嗜温微生物相比，在工业生物过程中使用嗜热微生物具有提高生物反应器反应速率和降低冷却成本的优点。此外，它使淀粉或木质纤维素的降解和发酵能够在同步糖化发酵 (SSF) 或联合生物加工 (CBP) 方法中在相同温度下发生。其天然的半纤维素分解能力和将二氧化碳转化为代谢能的能力。对生物基过程具有潜在吸引力的宿主。由于许多水解酶、碳水化合物转运蛋白和由名为半纤维素利用 (HUS) 基因座的基因组簇编码的调节元件，它可以有效降解半纤维素。有效基因工程工具的日益普及进一步开始发挥其作为多功能嗜热细胞工厂的潜力。一些菌株工程实例展示了作为微生物底盘用于生产散装和精细化学品的潜力，并提出了当前的研究瓶颈。最终，这篇综述提供了对不同代谢特征的整体概述，并讨论了旨在扩大天然代谢边界以开发工业相关菌株的研究。