Recurrent implantation failure (RIF) is a condition with a multifactorial basis. Recent research has focused on the role of genetic factors in the pathophysiology of RIF. Of particular note, miRNAs have been found to contribute to the pathogenesis of RIF. Several miRNA polymorphisms have been investigated in this context. Moreover, dysregulation of expression of a number of miRNAs, including miR-374a-5p, miR-145-5p, miR-30b-5p, miR-196b-5p, miR-22, miR-181 and miR-145 has been found in RIF. This review concentrates on the role of miRNAs in RIF to help in identification of the molecular basis for this condition and design of more effective methods for management of RIF, especially in a personalized manner that relies on the expression profiles of miRNAs in the peripheral blood or endometrium.

中文翻译：

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miRNA 在复发性植入失败病理学中的影响

复发性着床失败（RIF）是一种具有多因素基础的疾病。最近的研究重点是遗传因素在 RIF 病理生理学中的作用。特别值得注意的是，已经发现 miRNA 有助于 RIF 的发病机制。在这方面已经研究了几种 miRNA 多态性。此外，还发现许多 miRNA 的表达失调，包括 miR-374a-5p、miR-145-5p、miR-30b-5p、miR-196b-5p、miR-22、miR-181 和 miR-145在 RIF 中。本综述重点关注 miRNA 在 RIF 中的作用，以帮助识别这种情况的分子基础，并设计更有效的 RIF 管理方法，特别是依赖于外周血或中 miRNA 表达谱的个性化方式。子宫内膜。