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Neutrophil Percentage as a Potential Biomarker of Acute Kidney Injury Risk and Short-Term Prognosis in Patients with Acute Myocardial Infarction in the Elderly
Clinical Interventions in Aging ( IF 3.6 ) Pub Date : 2024-03-18 , DOI: 10.2147/cia.s455588 Qianwen Chen , Qingqing Gu , Anwen Yin , Dabei Cai , Tingting Xiao , Yu Wang , Yuan Ji , Qingjie Wang , Jun Wei , Ling Sun
Clinical Interventions in Aging ( IF 3.6 ) Pub Date : 2024-03-18 , DOI: 10.2147/cia.s455588 Qianwen Chen , Qingqing Gu , Anwen Yin , Dabei Cai , Tingting Xiao , Yu Wang , Yuan Ji , Qingjie Wang , Jun Wei , Ling Sun
Objective: This study aimed to explore the association of preoperative neutrophil percentage (NEUT%) with the risk of acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) having undergone coronary interventional therapy.
Methods: A single-center, retrospective and observational study was conducted. From December 2012 to June 2021, patients with AMI were enrolled and divided into AKI group and non-AKI group. The NEUT% in the two groups was compared. The association between NEUT% with the risk of post-AMI AKI was analyzed by univariate and multivariable logistic regression. Kaplan-Meier survival curve was drawn to evaluate the prognostic ability of NEUT% for short-term all-cause death following AMI.
Results: A total of 3001 consecutive patients were enrolled with an average age of 64.38 years. AKI occurred in 327 (10.9%) patients. The NEUT% was higher in the AKI group than in the non-AKI group ([76.65± 11.43]% versus [73.22± 11.83]%, P< 0.001). NEUT% was also identified as an independent risk factor for AKI in AMI patients after adjustment (OR=1.021, 95% CI: 1.010– 1.033, P < 0.001). Compared with those at the lowest quartile of NEUT%, the patients at quartiles 2– 4 had a higher risk of AKI (P for trend = 0.003). The odds of AKI increased by 29.0% as NEUT% increased by 1 standard deviation (OR=1.290, 95% CI: 1.087– 1.531, P = 0.004). After a median of 35 days follow-up, 93 patients died. Patients with a higher NEUT% presented a higher risk of all-cause death after AMI (Log rank: χ2 =24.753, P< 0.001).
Conclusion: In AMI patients, the peripheral blood NEUT% was positively associated with the odds of AKI and short-term all-cause mortality. NEUT% may provide physicians with more information about disease development and prognosis.
Keywords: neutrophil percentage, acute kidney injury, acute myocardial infarction
中文翻译：
中性粒细胞百分比作为老年急性心肌梗死患者急性肾损伤风险和短期预后的潜在生物标志物
目的：本研究旨在探讨接受冠状动脉介入治疗的急性心肌梗死（AMI）患者术前中性粒细胞百分比（NEUT%）与急性肾损伤（AKI）风险的关系。
方法：进行了一项单中心、回顾性和观察性研究。2012年12月至2021年6月入组AMI患者并分为AKI组和非AKI组。比较两组的NEUT%。通过单变量和多变量逻辑回归分析 NEUT% 与 AMI 后 AKI 风险之间的关联。绘制Kaplan-Meier生存曲线来评估NEUT%对AMI后短期全因死亡的预后能力。
结果：连续入组患者3001例，平均年龄64.38岁。327 名患者 (10.9%) 发生 AKI。AKI 组的 NEUT% 高于非 AKI 组（[76.65±11.43]% vs [73.22±11.83]%，P < 0.001）。调整后，NEUT% 也被确定为 AMI 患者发生 AKI 的独立危险因素（OR=1.021，95% CI：1.010–1.033，P < 0.001）。与处于 NEUT% 最低四分位数的患者相比，处于 2-4 四分位数的患者发生 AKI 的风险较高（趋势P = 0.003）。随着 NEUT% 增加 1 个标准差，AKI 的几率增加 29.0%（OR=1.290，95% CI：1.087–1.531，P = 0.004）。中位随访 35 天后，93 名患者死亡。NEUT% 较高的患者在 AMI 后出现全因死亡的风险较高（Log 等级：χ 2 =24.753，P < 0.001）。
结论： AMI患者外周血NEUT%与AKI发生率及短期全因死亡率呈正相关。NEUT% 可以为医生提供更多有关疾病发展和预后的信息。
Keywords:中性粒细胞百分比, 急性肾损伤, 急性心肌梗死
更新日期：2024-03-18
Methods: A single-center, retrospective and observational study was conducted. From December 2012 to June 2021, patients with AMI were enrolled and divided into AKI group and non-AKI group. The NEUT% in the two groups was compared. The association between NEUT% with the risk of post-AMI AKI was analyzed by univariate and multivariable logistic regression. Kaplan-Meier survival curve was drawn to evaluate the prognostic ability of NEUT% for short-term all-cause death following AMI.
Results: A total of 3001 consecutive patients were enrolled with an average age of 64.38 years. AKI occurred in 327 (10.9%) patients. The NEUT% was higher in the AKI group than in the non-AKI group ([76.65± 11.43]% versus [73.22± 11.83]%, P< 0.001). NEUT% was also identified as an independent risk factor for AKI in AMI patients after adjustment (OR=1.021, 95% CI: 1.010– 1.033, P < 0.001). Compared with those at the lowest quartile of NEUT%, the patients at quartiles 2– 4 had a higher risk of AKI (P for trend = 0.003). The odds of AKI increased by 29.0% as NEUT% increased by 1 standard deviation (OR=1.290, 95% CI: 1.087– 1.531, P = 0.004). After a median of 35 days follow-up, 93 patients died. Patients with a higher NEUT% presented a higher risk of all-cause death after AMI (Log rank: χ2 =24.753, P< 0.001).
Conclusion: In AMI patients, the peripheral blood NEUT% was positively associated with the odds of AKI and short-term all-cause mortality. NEUT% may provide physicians with more information about disease development and prognosis.
Keywords: neutrophil percentage, acute kidney injury, acute myocardial infarction
中文翻译：
中性粒细胞百分比作为老年急性心肌梗死患者急性肾损伤风险和短期预后的潜在生物标志物
目的：本研究旨在探讨接受冠状动脉介入治疗的急性心肌梗死（AMI）患者术前中性粒细胞百分比（NEUT%）与急性肾损伤（AKI）风险的关系。
方法：进行了一项单中心、回顾性和观察性研究。2012年12月至2021年6月入组AMI患者并分为AKI组和非AKI组。比较两组的NEUT%。通过单变量和多变量逻辑回归分析 NEUT% 与 AMI 后 AKI 风险之间的关联。绘制Kaplan-Meier生存曲线来评估NEUT%对AMI后短期全因死亡的预后能力。
结果：连续入组患者3001例，平均年龄64.38岁。327 名患者 (10.9%) 发生 AKI。AKI 组的 NEUT% 高于非 AKI 组（[76.65±11.43]% vs [73.22±11.83]%，P < 0.001）。调整后，NEUT% 也被确定为 AMI 患者发生 AKI 的独立危险因素（OR=1.021，95% CI：1.010–1.033，P < 0.001）。与处于 NEUT% 最低四分位数的患者相比，处于 2-4 四分位数的患者发生 AKI 的风险较高（趋势P = 0.003）。随着 NEUT% 增加 1 个标准差，AKI 的几率增加 29.0%（OR=1.290，95% CI：1.087–1.531，P = 0.004）。中位随访 35 天后，93 名患者死亡。NEUT% 较高的患者在 AMI 后出现全因死亡的风险较高（Log 等级：χ 2 =24.753，P < 0.001）。
结论： AMI患者外周血NEUT%与AKI发生率及短期全因死亡率呈正相关。NEUT% 可以为医生提供更多有关疾病发展和预后的信息。
Keywords:中性粒细胞百分比, 急性肾损伤, 急性心肌梗死
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