Amphiphilic cyclic dipeptides are efficient supramolecular hydrogelators. They can be combined with molecular photoswitches to produce light‐responsive soft materials, which can be applied in controlled drug delivery. Here it is reported that an arginine‐containing cyclic dipeptide decorated with ortho‐fluorinated azobenzene forms hydrogels under physiological conditions that can be reversibly liquefied upon exposure to visible light frequencies (green and violet, respectively). The addition of sodium alginate results in composite supramolecular hydrogels with increased gelating capacity supported with Coulombic interactions, which also reversibly dissipate upon irradiation.

中文翻译：

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基于库仑相互作用稳定的环状二肽的可见光触发超分子水凝胶

两亲性环状二肽是有效的超分子水凝胶剂。它们可以与分子光开关结合生产光响应软材料，可应用于受控药物输送。据报道，用邻氟化偶氮苯修饰的含精氨酸的环状二肽在生理条件下形成水凝胶，在暴露于可见光频率（分别为绿色和紫色）​​时可以可逆地液化。添加海藻酸钠导致复合超分子水凝胶在库仑相互作用的支持下具有增加的胶凝能力，并且在照射时也会可逆地消散。