The juxtaposition of two seemingly disparate physiological phenomena within the human body—namely, cancer and pregnancy—may offer profound insights into the intricate interplay between malignancies and the immune system. Recent investigations have unveiled striking similarities between the pivotal processes underpinning fetal implantation and successful gestation and those governing tumor initiation and progression. Notably, a confluence of features has emerged, underscoring parallels between the microenvironment of tumors and the maternal–fetal interface. These shared attributes encompass establishing vascular networks, cellular mobilization, recruitment of auxiliary tissue components to facilitate continued growth, and, most significantly, the orchestration of immune-suppressive mechanisms.

Our particular focus herein centers on the phenomenon of immune suppression and its protective utility in both of these contexts. In the context of pregnancy, immune suppression assumes a paramount role in shielding the semi-allogeneic fetus from the potentially hostile immune responses of the maternal host. In stark contrast, in the milieu of cancer, this very same immunological suppression fosters the transformation of the tumor microenvironment into a sanctuary personalized for the neoplastic cells.

Thus, the striking parallels between the immunosuppressive strategies deployed during pregnancy and those co-opted by malignancies offer a tantalizing reservoir of insights. These insights promise to inform novel avenues in the realm of cancer immunotherapy. By harnessing our understanding of the immunological events that detrimentally impact fetal development, a knowledge grounded in the context of conditions such as preeclampsia or miscarriage, we may uncover innovative immunotherapeutic strategies to combat cancer.

人体内两种看似不同的生理现象（即癌症和怀孕）的并置可能会为恶性肿瘤与免疫系统之间复杂的相互作用提供深刻的见解。最近的研究揭示了支持胎儿着床和成功妊娠的关键过程与控制肿瘤发生和进展的关键过程之间的惊人相似之处。值得注意的是，出现了一系列特征，强调了肿瘤微环境与母胎界面之间的相似之处。这些共同的属性包括建立血管网络、细胞动员、补充辅助组织成分以促进持续生长，以及最重要的是免疫抑制机制的协调。

我们在此特别关注免疫抑制现象及其在这两种情况下的保护作用。在怀孕期间，免疫抑制在保护半同种异体胎儿免受母体宿主潜在敌对免疫反应的影响方面发挥着至关重要的作用。与此形成鲜明对比的是，在癌症环境中，这种完全相同的免疫抑制促进了肿瘤微环境转变为肿瘤细胞的个性化避难所。

因此，怀孕期间采用的免疫抑制策略与恶性肿瘤所采用的免疫抑制策略之间的惊人相似之处提供了一系列诱人的见解。这些见解有望为癌症免疫治疗领域提供新的途径。通过利用我们对对胎儿发育产生不利影响的免疫事件的理解，这些知识是基于先兆子痫或流产等情况的知识，我们可能会发现对抗癌症的创新免疫治疗策略。