The prevalence of azole-resistant Aspergillus fumigatus is increasing worldwide and is speculated to be related to the use of azole pesticides. Aspergillus spp., the causative agent of aspergillosis, could be brought into domestic dwellings through food. However, studies on azole-resistant Aspergillus spp. in food products are limited. Therefore, we aimed to isolate Aspergillus spp. from processed foods and commercial agricultural products and performed drug susceptibility tests for azoles. Among 692 food samples, we isolated 99 strains of Aspergillus spp. from 50 food samples, including vegetables (22.9%), citrus fruits (26.3%), cereals (25.5%), and processed foods (1.8%). The isolates belonged to 18 species across eight sections: Aspergillus, Candidi, Clavati, Flavi, Fumigati, Nidulantes, Nigri, and Terrei. The most frequently isolated section was Fumigati with 39 strains, followed by Nigri with 28 strains. A. fumigatus and A. welwitschiae were the predominant species. Ten A. fumigatus and four cryptic strains, four A. niger cryptic strains, two A. flavus, and four A. terreus strains exceeded epidemiological cutoff values for azoles. A. tubingensis, A. pseudoviridinutans, A. lentulus, A. terreus, and N. hiratsukae showed low susceptibility to multi-azoles. Foods containing agricultural products were found to be contaminated with Aspergillus spp., with 65.3% of isolates having minimal inhibitory concentrations below epidemiological cutoff values. Additionally, some samples harbored azole-resistant strains of Aspergillus spp. Our study serves as a basis for elucidating the relationship between food, environment, and clinically important Aspergillus spp.

中文翻译：

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抗唑类曲霉属的分离。来自食品

世界范围内耐唑类烟曲霉的流行率正在增加，推测与唑类农药的使用有关。曲霉菌属曲霉菌病的病原体可以通过食物带入家庭住宅。然而，对唑类抗性曲霉属的研究。食品中的含量有限。因此，我们的目的是分离曲霉属。从加工食品和商业农产品中提取，并对唑类进行药物敏感性测试。在 692 个食品样本中，我们分离出 99 株曲霉菌。来自 50 个食品样本，包括蔬菜（22.9%）、柑橘类水果（26.3%）、谷物（25.5%）和加工食品（1.8%）。这些分离株属于 8 个科的 18 个物种：曲霉属、念珠菌属、Clavati 属、Flavi 属、Fumigati 属、Nidulantes 属、Nigri 属和 Terrei 属。最常分离的部分是 Fumigati，有 39 株菌株，其次是 Nigri，有 28 株菌株。A. fumigatus 和 A. welwitschiae 是主要物种。十种烟曲霉和四种隐性菌株、四种黑曲霉隐性菌株、两种黄曲霉和四种土曲霉菌株超过了唑类的流行病学临界值。Tubingensis、pseudoviridinutans、A. lentulus、A. terreus 和 N. hiratsukae 对多唑类药物的敏感性较低。含有农产品的食品被发现受到曲霉菌属污染，其中 65.3% 的分离株的最低抑制浓度低于流行病学临界值。此外，一些样品含有曲霉属的唑类抗性菌株。我们的研究为阐明食物、环境和临床上重要的曲霉菌属之间的关系奠定了基础。