当前位置：
X-MOL 学术
›
Int. J. Cancer
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Association of female reproductive and hormonal factors with gallbladder cancer risk in Asia: A pooled analysis of the Asia Cohort Consortium
International Journal of Cancer ( IF 6.4 ) Pub Date : 2024-03-13 , DOI: 10.1002/ijc.34916 Aesun Shin 1, 2, 3, 4 , Sooyoung Cho 1, 4 , Sarah Krull Abe 5 , Md Rashedul Islam 5, 6 , Md Shafiur Rahman 5, 7 , Eiko Saito 8 , Sayada Zartasha Kazmi 1 , Ryoko Katagiri 9, 10 , Melissa Merritt 11 , Ji‐Yeob Choi 12 , Xiao‐Ou Shu 13 , Norie Sawada 9 , Akiko Tamakoshi 14 , Woon‐Puay Koh 15, 16 , Ritsu Sakata 17 , Atsushi Hozawa 18 , Jeongseon Kim 19 , Sue K. Park 1, 2, 3 , Sun‐Seog Kweon 20 , Wanqing Wen 13 , Shoichiro Tsugane 9, 21 , Takashi Kimura 14 , Jian‐Min Yuan 22, 23 , Seiki Kanemura 18 , Yumi Sugawara 18 , Min‐Ho Shin 20 , Habibul Ahsan 24 , Paolo Boffetta 25, 26 , Kee Seng Chia 27 , Keitaro Matsuo 28, 29 , You‐Lin Qiao 30 , Nathaniel Rothman 31 , Wei Zheng 13 , Manami Inoue 5 , Daehee Kang 1, 3
International Journal of Cancer ( IF 6.4 ) Pub Date : 2024-03-13 , DOI: 10.1002/ijc.34916 Aesun Shin 1, 2, 3, 4 , Sooyoung Cho 1, 4 , Sarah Krull Abe 5 , Md Rashedul Islam 5, 6 , Md Shafiur Rahman 5, 7 , Eiko Saito 8 , Sayada Zartasha Kazmi 1 , Ryoko Katagiri 9, 10 , Melissa Merritt 11 , Ji‐Yeob Choi 12 , Xiao‐Ou Shu 13 , Norie Sawada 9 , Akiko Tamakoshi 14 , Woon‐Puay Koh 15, 16 , Ritsu Sakata 17 , Atsushi Hozawa 18 , Jeongseon Kim 19 , Sue K. Park 1, 2, 3 , Sun‐Seog Kweon 20 , Wanqing Wen 13 , Shoichiro Tsugane 9, 21 , Takashi Kimura 14 , Jian‐Min Yuan 22, 23 , Seiki Kanemura 18 , Yumi Sugawara 18 , Min‐Ho Shin 20 , Habibul Ahsan 24 , Paolo Boffetta 25, 26 , Kee Seng Chia 27 , Keitaro Matsuo 28, 29 , You‐Lin Qiao 30 , Nathaniel Rothman 31 , Wei Zheng 13 , Manami Inoue 5 , Daehee Kang 1, 3
Affiliation
|
The female predominance of gallbladder cancer (GBC) has led to a hypothesis regarding the hormone‐related aetiology of GBC. We aimed to investigate the association between female reproductive factors and GBC risk, considering birth cohorts of Asian women. We conducted a pooled analysis of 331,323 women from 12 cohorts across 4 countries (China, Japan, Korea, and Singapore) in the Asia Cohort Consortium. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) to assess the association between reproductive factors (age at menarche, parity, age at first delivery, breastfeeding, and age at menopause) and GBC risk. We observed that a later age at menarche was associated with an increased risk of GBC (HR 1.4, 95% CI 1.16–1.70 for 17 years and older vs. 13–14 years), especially among the cohort born in 1940 and later (HR 2.5, 95% CI 1.50–4.35). Among the cohort born before 1940, women with a later age at first delivery showed an increased risk of GBC (HR 1.56, 95% CI 1.08–2.24 for 31 years of age and older vs. 20 years of age and younger). Other reproductive factors did not show a clear association with GBC risk. Later ages at menarche and at first delivery were associated with a higher risk of GBC, and these associations varied by birth cohort.
更新日期：2024-03-13
京公网安备 11010802027423号