The colloidosome, as a kind of Pickering microcapsule, offers a highly functionalizable approach for encapsulation, but current studies mainly focus on shells that lack real-time modulated permeability. Herein, a scalable spray drying method was employed to fabricate temperature/near-infrared (NIR)/magnetic multi-stimuli responsive colloidosomes with adjustable permeability, facilitating intelligent transmembrane transport of molecules. The colloidosomes assembled with SiO₂/polydopamine/poly (N-isopropyl acrylamide) nanoparticles can be heated from 25°C to 50°C within 5 min upon NIR exposure. The permeability of shells regulated by temperature and NIR allows for real-time remote control. Yeast cells, as an example, are encapsulated within colloidosomes. The decomposition rate of H₂O₂ varies with temperature (25–45°C) and NIR intensity (0.5–1 W cm⁻²), which can attain a more than sixfold increase in the rate constant of pseudo-first-order kinetic model. Furthermore, the strategy was expanded by encapsulating doxorubicin/UiO-66 particles, highlighting its great potential in realms of multi-stimuli responsive colloidosomes applications.

中文翻译：

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用于智能跨膜运输的多刺激响应胶体体的高效构建


胶体体作为一种Pickering微胶囊，提供了一种高度功能化的封装方法，但目前的研究主要集中在缺乏实时调节渗透性的壳上。在此，采用可扩展的喷雾干燥方法来制造具有可调节渗透性的温度/近红外（NIR）/磁性多刺激响应胶体体，促进分子的智能跨膜运输。用SiO ₂ /聚多巴胺/聚(N-异丙基丙烯酰胺)纳米粒子组装的胶体体在近红外照射下可以在5分钟内从25°C加热到50°C。外壳的渗透性由温度和近红外调节，可实现实时远程控制。例如，酵母细胞被封装在胶体体内。 H ₂ O ₂ 的分解速率随温度（25–45°C）和 NIR 强度（0.5–1 W cm ⁻² ）的变化而变化，这可以准一级动力学模型的速率常数增加了六倍以上。此外，通过封装阿霉素/UiO-66颗粒扩展了该策略，突显了其在多刺激响应胶体体应用领域的巨大潜力。