Recent studies have shown that the risks of mental disorders resulting from vitamin D deficiency, such as depression, anxiety and stress, can be affected by various high-risk alleles. Among the genes interacting with environmental factors are those associated with vitamin D binding protein (DBP) that affects the status of 25- OH vitamin D. Therefore, the present study aimed to determine the interaction between dietary patterns and gene variants on mental health status in adults. This cross-sectional study was conducted on a random sample of adult participants ( = 265 and 18–55 years old) in Tehran. Major dietary patterns were determined using principal component analysis (PCA) method on 24 food groups, using a valid and reliable 147-item food frequency questionnaire (FFQ). genotypes were determined by polymerase chain reactions - restriction fragment length polymorphism (PCR-RFLP). Data about the mental health status were collected using the Depression, Anxiety, Stress Score (DASS-21). Results demonstrated strong interactions between higher adherence to healthy dietary patterns in individuals with the major allele (low-risk allele) carriers of rs7041 (GG genotype), in relation to reduced stress score (OR= -2.54, 95 % CI = -4.60 to -0.48, P interaction = 0.02). Also, individuals with higher adherence to healthy dietary patterns with GG genotype of rs7041 indicated reduced stress score, but it was not significant (OR = -1.84, 95 % CI = 0.18 to -3.86, P interaction = 0.07). The present evidence indicates that interactions between healthy dietary patterns with variants (rs7041 - GG genotype) may effectively reduce the odds of mental disorders , especially in stress, through consuming healthy food groups and inherited low-risk alleles.

中文翻译：

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维生素 D 结合蛋白变体与主要饮食模式之间的相互作用对表面健康成年人心理健康状况的影响

最近的研究表明，维生素 D 缺乏导致的精神障碍（例如抑郁、焦虑和压力）的风险可能受到各种高风险等位基因的影响。在与环境因素相互作用的基因中，有一些与影响 25-OH 维生素 D 状态的维生素 D 结合蛋白 (DBP) 相关的基因。因此，本研究旨在确定饮食模式和基因变异之间的相互作用对心理健康状况的影响。成年人。这项横断面研究是对德黑兰成年参与者（= 265 岁和 18-55 岁）的随机样本进行的。使用有效且可靠的 147 项食物频率问卷 (FFQ)，通过主成分分析 (PCA) 方法确定 24 个食物组的主要饮食模式。通过聚合酶链式反应-限制性片段长度多态性（PCR-RFLP）确定基因型。使用抑郁、焦虑、压力评分 (DASS-21) 收集有关心理健康状况的数据。结果表明，rs7041（GG 基因型）主要等位基因（低风险等位基因）携带者对健康饮食模式的较高依从性与压力评分降低之间存在很强的相互作用（OR= -2.54，95 % CI = -4.60 至-0.48，P 相互作用 = 0.02)。此外，具有较高坚持健康饮食模式且具有 rs7041 GG 基因型的个体表明压力评分降低，但并不显着（OR = -1.84，95 % CI = 0.18 至 -3.86，P 交互作用 = 0.07）。目前的证据表明，健康饮食模式与变异体（rs7041 - GG 基因型）之间的相互作用可以通过食用健康食物组和遗传低风险等位基因，有效降低精神障碍的几率，特别是在压力下。