The highly efficient synthesis of benzoxazole, benzothiazole and benzimidazole has attracted much attention due to their superior biological activities. However, developing environmentally friendly and poisoning-resistant catalysts in heterogeneous catalytic systems remains a critical challenge. Herein, an atomically dispersed Co₁/NC catalyst was fabricated by facile pyrolysis of a zeolitic imidazolate framework (ZnCo-ZIF). The Co₁/NC catalyst exhibited excellent oxidation catalysis, sulfur-resistance and reusability performance. The mass specific activity (MSA) of Co₁/NC was up to 42.0 mol_2-PBO mol_Co⁻¹ h⁻¹, much higher than that of the Co/NC nano-catalyst (15.6 mol_2-PBO mol_Co⁻¹ h⁻¹). Mechanism studies showed that O₂ was activated by atomically dispersed Co active species to form ¹O₂ and ˙O₂⁻, which were responsible for the dehydrogenation of the key imine intermediates to produce 2-phenylbenzoxazole (2-PBO). The current work represents a novel feasible strategy for the synthesis of bioactive heterocyclic compounds using efficient, stable and green heterogeneous catalysts.

中文翻译：

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一种原子分散的钴催化剂，用于在环境氧气条件下有效氧化制造苯并杂环化合物

苯并恶唑、苯并噻唑和苯并咪唑的高效合成因其优异的生物活性而备受关注。然而，在多相催化体系中开发环境友好且抗中毒的催化剂仍然是一个严峻的挑战。在此，通过沸石咪唑酯骨架(ZnCo-ZIF)的轻松热解制备了原子分散的Co ₁ /NC催化剂。 Co ₁ /NC催化剂表现出优异的氧化催化、抗硫和可重复使用性能。 Co ₁ /NC的质量比活度（MSA）高达42.0 mol _2-PBO mol _Co ^-1 h ^-1，远高于Co/NC纳米催化剂的质量比活度（15.6 mol _2-PBO mol _Co ^-1 h ^-1 )。机理研究表明，O ₂被原子分散的Co活性物质激活，形成¹ O ₂和˙O ₂ ^-，它们负责关键亚胺中间体的脱氢，生成2-苯基苯并恶唑(2-PBO)。目前的工作代表了一种使用高效、稳定和绿色多相催化剂合成生物活性杂环化合物的新颖可行的策略。