Climbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of rewards, leading to bursts of excitatory postsynaptic potentials (EPSPs) in Purkinje cells. The number of EPSPs is a crucial variable when the brain is learning a new motor skill. Yet, we do not know what determines the number of EPSPs. Here, we measured the effect of nucleo-olivary stimulation on periorbital elicited climbing fiber responses through in-vivo intracellular Purkinje cell recordings in decerebrated ferrets. The results show that while nucleo-olivary stimulation decreased the probability of a response occurring at all, it did not reduce the number of EPSPs. The results suggest that nucleo-olivary stimulation does not influence the number of EPSPs in climbing fiber bursts.

连接下橄榄细胞和浦肯野细胞的攀爬纤维形成神经系统最强的神经连接。这些纤维在运动错误或奖励预期等关键事件发生后激活，导致浦肯野细胞中兴奋性突触后电位（EPSP）的爆发。当大脑学习新的运动技能时，EPSP 的数量是一个关键变量。然而，我们不知道是什么决定了 EPSP 的数量。在这里，我们通过去大脑雪貂的体内细胞内浦肯野细胞记录测量了核橄榄刺激对眶周引发的攀爬纤维反应的影响。结果表明，虽然核橄榄刺激完全降低了反应发生的可能性，但它并没有减少 EPSP 的数量。结果表明，核橄榄刺激不会影响攀爬纤维爆发中 EPSP 的数量。