Novel 2-methyl-5-phenyl-7-amino-[1,3,4]-thiadiazolo[3,2-a]pyrimidine-6-carbonitrile derivatives 3 were synthesized from 2-amino-5-methyl-1,3,4-thiadiazole 1 and benzylidinemalononitrile 2 in ethanol by refluxing the mixture with catalytic amount of NaOH. The structures of all compounds were characterized by elemental analysis, IR, MS, and ¹H nuclear magnetic resonance spectra. The newly synthesized compounds were also seen as an affective fungicide against Rhizoctonia solani and Trichoderma sp., two fungal microbes causing diseases in rice plants.

中文翻译：

---

2-甲基-5-苯基-7-氨基-[1,3,4]-噻二唑并[3,2-a]嘧啶-6-甲腈衍生物的一锅法合成方法及抗真菌评价

以2-氨基-5-甲基-1,3为原料合成了新型2-甲基-5-苯基-7-氨基-[1,3,4]-噻二唑并[3,2- a ]嘧啶-6-甲腈衍生物3 ,4-噻二唑1和亚苄基丙二腈2在乙醇中通过与催化量的NaOH回流混合物而得到。所有化合物的结构均通过元素分析、IR、MS和^1H核磁共振谱进行了表征。新合成的化合物也被视为针对立枯丝核菌和木霉这两种引起水稻疾病的真菌微生物的情感杀菌剂。