Five-membered indazoles are recognized as a special scaffold having a broad spectrum of pharmacological properties among other heterocyclic compounds. New methods must be developed for the effective synthesis of 2H-indazole because of the exceptionally high biological activity of compounds containing a 2H-indazole core. We present the ionic liquid-supported copper-catalyzed one-pot synthesis of 2H-indazoles under microwave irradiation, continuing our ongoing investigation of the potential uses of bioactive compounds produced in the lab. The use of microwave and ionic liquid-supported catalyst makes this process greener and more highly energy efficient than the conventional reported methods. Overall, by forming consecutive C-N and N-N bonds with the help of an ionic liquid-supported copper catalyst, we have developed a novel green one-pot technique for the synthesis of the 2H-indazole motifs in very high yield.

中文翻译：

---

微波辐射下离子液体支持铜催化合成2H-吲唑

五元吲唑被认为是其他杂环化合物中具有广谱药理特性的特殊支架。由于含有 2 H-吲唑核心的化合物具有极高的生物活性，因此必须开发新的方法来有效合成 2 H-吲唑。我们提出了微波辐射下离子液体支持的铜催化一锅法合成 2 H-吲唑，继续我们对实验室生产的生物活性化合物的潜在用途的持续研究。微波和离子液体负载催化剂的使用使得该过程比传统报道的方法更加绿色且能源效率更高。总的来说，通过在离子液体负载的铜催化剂的帮助下形成连续的CN和NN键，我们开发了一种新型绿色一锅法技术，以非常高的产率合成2H-吲唑基序。