Long non-coding RNAs (lncRNA) are functional RNAs, with over 200 nucleotides in length and lacking protein-coding potential. Studies have indicated that lncRNAs are important gene regulators under physiological conditions. Aberrant lncRNA expression is associated with the initiation and progression of various diseases, including cancers. High-throughput transcriptome analyses have revealed thousands of lncRNAs as putative tumor suppressors or promoters in various cancers, but the detailed molecular mechanisms of each lncRNA remain unclear. Downregulated RNA In Cancer, inhibitor of cell invasion and migration () (also known as and ) is a lncRNA that inhibits or promotes cancer progression with several modes of action. was originally identified as a tumor-suppressive lncRNA in prostate adenocarcinoma. Subsequent studies also revealed that it has an anti-tumor role in glioblastoma, triple-negative breast cancer, and stomach adenocarcinoma. However, exhibits oncogenic functions in other malignancies, such as lung adenocarcinoma and esophageal carcinoma, indicating its highly context-dependent effects on cancer progression and clinical outcomes. and its associated pathways regulate various biological processes, including proliferation, invasion, metastasis, autophagy, and neuroendocrine function. This review introduces the multifaceted roles of , particularly in cancer progression, and discusses its biological significance and clinical implications.

中文翻译：

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长链非编码 RNA DRAIC 在癌症进展中的多方面作用

长非编码RNA (lncRNA) 是功能性RNA，长度超过200 个核苷酸，缺乏蛋白质编码潜力。研究表明lncRNA是生理条件下重要的基因调控因子。异常的 lncRNA 表达与包括癌症在内的各种疾病的发生和进展有关。高通量转录组分析揭示了数千种 lncRNA 作为各种癌症中假定的肿瘤抑制因子或启动子，但每种 lncRNA 的详细分子机制仍不清楚。下调 RNA 在癌症中，细胞侵袭和迁移抑制剂 ()（也称为 和 ）是一种 lncRNA，可通过多种作用模式抑制或促进癌症进展。最初被鉴定为前列腺腺癌中的肿瘤抑制性 lncRNA。随后的研究还表明，它对胶质母细胞瘤、三阴性乳腺癌和胃腺癌具有抗肿瘤作用。然而，它在其他恶性肿瘤（如肺腺癌和食管癌）中表现出致癌功能，表明其对癌症进展和临床结果的影响高度依赖于背景。及其相关途径调节各种生物过程，包括增殖、侵袭、转移、自噬和神经内分泌功能。本综述介绍了 的多方面作用，特别是在癌症进展中的作用，并讨论了其生物学意义和临床意义。