Colorectal cancer (CRC) is the 2nd most common cancer and 3rd most common cause of death in the Middle East and Northern Africa (MENA) region. We aimed to explore CRC stage at diagnosis data from population‐based cancer registries in MENA countries. In 2021, we launched a Global Initiative for Cancer Registry Development (GICR) survey on staging practices and breast and CRC stage distributions in MENA. According to the survey results, population‐based data on TNM stage for CRC were available from six registries in five countries (Kuwait, Morocco, Oman, Türkiye, UAE). The proportion of cases with unknown TNM stage ranged from 14% in Oman to 47% in Casablanca, Morocco. The distribution of CRC cases with known stage showed TNM stage IV proportions of 26–45%, while the proportions of stage I cancers were lowest in Morocco (≤7%), and highest (19%) in Izmir, Türkiye. Summary extent of disease data was available from six additional registries and four additional countries (Algeria, Bahrain, Iraq, Qatar). In summary, the proportions of CRC diagnosed with distant metastases in Oman, Bahrain and UAE were lower than other MENA countries in our study, but higher than in European and the US populations. Harmonising the use of staging systems and focusing stage data collection efforts on major cancers, such as CRC, is needed to monitor and evaluate progress in CRC control in the region.

中文翻译：

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中东和北非结直肠癌的诊断阶段：基于人群的癌症登记研究

结直肠癌 (CRC) 是中东和北非 (MENA) 地区第二大常见癌症和第三大常见死亡原因。我们的目的是根据中东和北非国家基于人群的癌症登记处的诊断数据来探索 CRC 分期。2021 年，我们发起了一项关于中东和北非地区分期实践以及乳腺癌和结直肠癌分期分布的全球癌症登记发展倡议 (GICR) 调查。根据调查结果，结直肠癌 TNM 分期的基于人群的数据可从五个国家（科威特、摩洛哥、阿曼、土耳其、阿联酋）的六个登记处获得。TNM 分期未知的病例比例从阿曼的 14% 到摩洛哥卡萨布兰卡的 47%。已知分期的CRC病例分布显示，TNM IV期比例为26-45%，而I期癌症比例在摩洛哥最低（≤7%），在土耳其伊兹密尔最高（19%）。疾病数据的概要范围可从另外六个登记处和另外四个国家（阿尔及利亚、巴林、伊拉克、卡塔尔）获得。总之，阿曼、巴林和阿联酋被诊断为远处转移的结直肠癌比例低于我们研究中的其他中东和北非国家，但高于欧洲和美国人群。需要协调分期系统的使用并将分期数据收集工作重点放在结直肠癌等主要癌症上，以监测和评估该地区结直肠癌控制的进展。