Recent developments in synthetic strategies and pharmacological outcomes of synthetic xanthine oxidase inhibitors: A comprehensive review,Journal of Heterocyclic Chemistry

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Recent developments in synthetic strategies and pharmacological outcomes of synthetic xanthine oxidase inhibitors: A comprehensive review
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2024-03-05 , DOI: 10.1002/jhet.4796
Gurinder Kaur _{1,

2} , Rajiv Sharma _{1,

3} , Ashu ₂ , Geetakshi Arora ₄ , Atamjit Singh ₂ , Preet Mohinder Singh Bedi ₂ , Kundan Singh Bora ₅

Affiliation

Xanthine oxidase is an important enzyme in purine metabolism that converts hypoxanthine to xanthine and subsequently xanthine to uric acid. Its elevated levels result in an abnormal accumulation of uric acid that results in gout and other pathological conditions, which makes it a prime target for the management of gout. Considering this, numerous reports have been published by the various research groups across the globe focusing on the development of effective xanthine oxidase inhibitors. On that ground, numerous review articles are also available describing the pharmacological outputs of these reports, but a composition highlighting the synthetic strategies used in these research works is still missing. This review will focus on various synthetic strategies adopted by different research groups in developing xanthine oxidase inhibitors with their pharmacological outcomes, along with structure activity relationships. This review will help researchers and pharmaceutical chemists in the design and development of new xanthine oxidase inhibitor leads that are highly efficient and have fewer side effects than existing ones.

中文翻译：

合成黄嘌呤氧化酶抑制剂的合成策略和药理学结果的最新进展：综合综述

黄嘌呤氧化酶是嘌呤代谢中的重要酶，可将次黄嘌呤转化为黄嘌呤，然后将黄嘌呤转化为尿酸。其水平升高会导致尿酸异常积累，从而导致痛风和其他病理状况，这使其成为痛风治疗的主要目标。考虑到这一点，全球各个研究小组发表了大量报告，重点关注有效黄嘌呤氧化酶抑制剂的开发。在此基础上，还有许多评论文章描述了这些报告的药理学成果，但仍然缺少强调这些研究工作中使用的合成策略的文章。本综述将重点关注不同研究小组在开发黄嘌呤氧化酶抑制剂时采用的各种合成策略及其药理学结果以及结构活性关系。本次综述将帮助研究人员和药物化学家设计和开发新型黄嘌呤氧化酶抑制剂先导化合物，这些先导化合物比现有药物更高效且副作用更少。

更新日期：2024-03-05

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