Declining energy and increasing fatigue, common in older age, predict neurodegenerative conditions, but their neural substrates are not known. We examined brain resting state connectivity in relation to declining self-reported energy levels (SEL) and occurrence of fatigue over time. We examined resting-state functional MRI in 272 community dwelling older adults participating in the Health Aging and Body Composition Study (mean age 83 years; 57.4 % female; 40.8 % Black) with measures of fatigue and SEL collected at regular intervals over the prior ten years. Functional connectivity (FC) between cortex and striatum was examined separately for sensorimotor, executive, and limbic functional subregions. Logistic regression tested the association of FC in each network with prior fatigue state (reporting fatigue at least once or never reporting fatigue), and with SEL decline (divided into stable or declining SEL groups) and adjusted for demographic, physical function, mood, cognition, and comorbidities. Higher cortico-striatal FC in the right limbic network was associated with lower odds of reporting fatigue (better) at least once during the study period (adjusted odds ratio [95 % confidence interval], -value: (0.747 [0.582, 0.955], 0.020), independent of SEL. Higher cortico-striatal FC in the right executive network was associated with higher odds of declining SEL (worse) during the study period (adjusted odds ratio [95 % confidence interval], -value: (1.31 [1.01, 1.69], 0.041), independent of fatigue. Associations with other networks were not significant. In this cohort of older adults, the cortico-striatal functional connectivity of declining SEL appears distinct from that underlying fatigue. Studies to further assess the neural correlates of energy and fatigue, and their independent contribution to neurodegenerative conditions are warranted.

中文翻译：

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10 岁以上老年人样本中的疲劳和感知能量：神经相关性的静息状态功能连接研究

老年人中常见的能量下降和疲劳增加预示着神经退行性疾病，但其神经基础尚不清楚。我们检查了大脑静息状态连接与自我报告能量水平（SEL）下降和随着时间的推移疲劳发生的关系。我们检查了参与健康老龄化和身体成分研究的 272 名社区居住老年人（平均年龄 83 岁；57.4% 女性；40.8% 黑人）的静息态功能 MRI，并在过去 10 年定期收集疲劳和 SEL 测量值年。分别检查皮层和纹状体之间的感觉运动、执行和边缘功能子区域的功能连接（FC）。 Logistic 回归测试了每个网络中 FC 与先前疲劳状态（至少报告一次疲劳或从不报告疲劳）以及 SEL 下降（分为稳定或下降的 SEL 组）的关联，并根据人口统计、身体功能、情绪、认知进行调整和合并症。右侧边缘网络中较高的皮质纹状体 FC 与研究期间至少一次报告疲劳（更好）的较低几率相关（调整后的比值比 [95% 置信区间]，-值：（0.747 [0.582, 0.955]， 0.020），独立于 SEL。右侧执行网络中较高的皮质纹状体 FC 与研究期间 SEL 下降（更差）的较高几率相关（调整后的比值比 [95% 置信区间]，-值：（1.31 [1.01 ，1.69]，0.041），与疲劳无关。与其他网络的关联并不显着。在这组老年人中，SEL 下降的皮质纹状体功能连接似乎与潜在的疲劳不同。进一步评估神经相关性的研究能量和疲劳，以及它们对神经退行性疾病的独立贡献是有根据的。